| 4738_4 | |
| Organism | Mus musculus (mouse) |
| Function | Atg8 conjugation system |
| Cluster | 8 |
| Symbol | Ulk3 |
| Synonyms | 1200015E14Rik |
| Gene Name | unc-51-like kinase 3 |
| Other Name | Ulk3 |
| Gene ID | 71742 |
| Nucleotide | NM_027895.1 XM_006511451.2 XR_379456.2 XR_379457.2 XR_379458.1 XR_379459.1 XR_870766.1 XR_870767.1 |
| GI | 242332525 568962087 |
| Protein | NP_082171.1 XP_006511514.1 |
| Genomic | AC_000031.1 NC_000075.6 NT_039474.8 NW_001030907.1 |
| UniProt | Q3U3Q1 |
| Description | unc-51-like kinase 3 |
| PDB Structure | - |
| Predicted Location | Cytoplasm. |
| Complex | - |
| Interaction | - |
| Interaction (Human) | [Search PPI (67)] |
| VaProS | Q3U3Q1 |
| Function (UniProt) | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy (By similarity). |
| UniGene | Mm.155877 |
| Related Papers | 10349636 11042159 11076861 11125038 11217851 12466851 12477932 15489334 15782199 16141072 16141073 20643644 21267068 |
| Predicted Disordered Regions | [Dichot] |
| Sequence | >NP_082171.1 MAGPSWGLPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDNDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPQLSLDCRDLLQRLLERDPARRISFKDFFAHPWVDLEHMPSGESLAQARALVVEAVKKDQEGDAAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGTTVQELLREMARDKPRLLAALEVASAALAKEEEAGKEQDALDLYQHSLGELLVLLAAEAPGRRRELLHTEVQNLMARAEYLKEQIKIRESHWEAESLDKEGLSESVRSSCTLQ >XP_006511514.1 MAGPSWGLPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDNDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVGVILYAPSSAPTLPRLPGPVAATSRAGPRPSNLLQGLLCPSLGGPGAHAQWGEPGTGKGPCGGGCEEGPGGGCCRCPVALLQGSGLLCTCATLRSGCPEEGGN |