| 616_4 | |
| Organism | Schizosaccharomyces pombe |
| Function | Atg8 conjugation system |
| Cluster | 8 |
| Symbol | atg8 |
| Synonyms | - |
| Gene Name | - |
| Other Name | - |
| Gene ID | 2541386 |
| Nucleotide | NM_001022452.2 |
| GI | 19113323 |
| Protein | NP_596531.1 |
| Genomic | NC_003423.3 |
| UniProt | O94272 |
| Description | autophagy associated protein Atg8 |
| PDB Structure | - |
| Predicted Location | Cytoplasmic vesicle, cvt vesicle membrane. |
| Complex | - |
| Interaction | - |
| Interaction (Human) | [Search PPI (67)] |
| VaProS | O94272 |
| Function (UniProt) | Ubiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation. With atg4, mediates the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity). Contributes to the maintenance of cell viability under conditions of nitrogen-depletion. Plays a role in meiosis and sporulation and contributes to oxidative stress resistance. |
| UniGene | - |
| Related Papers | 11859360 16823372 17295836 20070859 20133687 20531409 23950735 |
| Predicted Disordered Regions | [Dichot] |
| Sequence | >NP_596531.1 MRSQFKDDFSFEKRKTESQRIREKYPDRIPVICEKVDKSDIAAIDKKKYLVPSDLTVGQFVYVIRKRIKLSPEKAIFIFIDEILPPTAALMSTIYEEHKSEDGFLYITYSGENTFGTVFPF |