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Entry URI http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17468263i
Entry name Shedge Vikas et al. 2007 Apr. Plant Cell 19(4):1251-64.
Title Plant mitochondrial recombination surveillance requires unusual RecA and MutS homologs.
Authors Arrieta-Montiel Maria|Christensen Alan C|Mackenzie Sally A|Shedge Vikas
Abstract For >20 years, the enigmatic behavior of plant mitochondrial genomes has been well described but not well understood. Chimeric genes appear, and occasionally are differentially replicated or expressed, with significant effects on plant phenotype, most notably on male fertility, yet the mechanisms of DNA replication, chimera formation, and recombination have remained elusive. Using mutations in two important genes of mitochondrial DNA metabolism, we have observed reproducible asymmetric recombination events occurring at specific locations in the mitochondrial genome. Based on these experiments and existing models of double-strand break repair, we propose a model for plant mitochondrial DNA replication, chimeric gene formation, and the illegitimate recombination events that lead to stoichiometric changes. We also address the physiological and developmental effects of aberrant events in mitochondrial genome maintenance, showing that mitochondrial genome rearrangements, when controlled, influence plant reproduction, but when uncontrolled, lead to aberrant growth phenotypes and dramatic reduction of the cell cycle.
Pubmed ID 17468263
Journal The Plant cell
Volume 19
Issue 4
Pages 1251-64
Publication date 2007 Apr
Num of phenotype gene 2