| 796 | |
| Entry URI | http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u19004800i |
| Entry name | Gu Ying et al. 2008 Nov. Proc. Natl. Acad. Sci. U.S.A. 105(46):18064-9. |
| Title | Prefoldin 6 is required for normal microtubule dynamics and organization in Arabidopsis. |
| Authors | DeBolt Seth|Deng Zhiping|Gu Ying|Paredez Alexander R|Somerville Chris|Wang Zhi-Yong |
| Abstract | Newly translated tubulin molecules undergo a series of complex interactions with nascent chain-binding chaperones, including prefoldin (PFD) and chaperonin-containing TCP-1 (CCT). By screening for oryzalin hypersensitivity, we identified several mutants of Arabidopsis that have lesions in PFD subunits. The pfd6-1 mutant exhibits a range of microtubule defects, including hypersensitivity to oryzalin, defects in cell division, cortical array organization, and microtubule dynamicity. Consistent with phenotypic analysis, proteomic analysis indicates several isoforms of tubulins were reduced in pfd6-1. These results support the concept that the function of microtubules is critically dependent on the absolute amount of tubulins. |
| Pubmed ID | 19004800 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 105 |
| Issue | 46 |
| Pages | 18064-9 |
| Publication date | 2008 Nov |
| Num of phenotype gene | 0 |