| 136 | |
| GRIP ID | 136 |
| Main Title | Information about hetero oligomer between serotonin type 2a (5HT2aR) and metabotropic glutamate receptor type 2 (mGluR2), and interfaces of 5HT2aR |
| GPCR Class | A |
| GPCR Subfamily | Serotonin |
| GPCR Subtype | Type 2a |
| GPCR Name | 5HT2aR |
| Partner Class | C |
| Partner Subfamily | Metabotropic |
| Partner Subtype | Type 2 |
| Partner Name | mGluR2 |
| Evidence | Experiment |
| Annotations | mGluR2 interacts through specific transmembrane helices with the serotonin 5-HT2AR to form functional complexes in brain cortex. The 5-HT2AR mGluR2 complex triggers unique cellular responses when targeted by hallucinogenic drugs, and activation of mGluR2 abolishes hallucinogen-specific signalling and behavioural responses. This complex is a promising new target for the treatment of psychosis, which is associated with schizophrenia. |
| Articles | 18297054 |
| Methods | BRET, ColP, colocalization |
| Target | NP_000612.1 |
| Other Partners | - |
| Disease | - |
| Interface | - |
| Mutation Information | |
| Experimentaly Information | |
| Predicted Information | |