| 141 | |
| GRIP ID | 141 |
| Main Title | Information about hetero oligomer between neurotensin receptors type 1 and type 2 (NTR1 and NTR2), and interfaces of NTR1 |
| GPCR Class | A |
| GPCR Subfamily | Neurotensin |
| GPCR Subtype | Type 1 |
| GPCR Name | NTR1 |
| Partner Class | A |
| Partner Subfamily | Neurotensin |
| Partner Subtype | Type 2 |
| Partner Name | NTR2 |
| Evidence | Experiment |
| Annotations | TM2-TM4 regions of human NTR2 are crucial for the formation of the dimerization interface. Co-expression of hNTR2 suppressed hNTR1-mediated adenylate cyclase/cAMP and phospholipase C activation. Coexpression of hNTR2 caused the retention of hNTR1 in sub-cellular compartments, although tagged hNTR1 expressed alone were localized to the plasma membrane. Therefore, heterodimerization with hNTR2 is considered to lead to the recruitment of hNTR1 to the plasma membrane. |
| Articles | 19968961 |
| Methods | Chimera constructs, coexpression, confocal microscopy |
| Target | NP_002522.2 |
| Other Partners | - |
| Disease | - |
| Interface | - |
| Mutation Information | |
| Experimentaly Information | Experiment Information |
| Predicted Information | |