144 | |
GRIP ID | 144 |
Main Title | Information about hetero oligomer between CB1 cannabinoid receptor (CB1R) and D2 dopamine receptor (D2R), and interfaces of CB1R |
GPCR Class | A |
GPCR Subfamily | Cannabinoid |
GPCR Subtype | CB1 |
GPCR Name | CB1R |
Partner Class | A |
Partner Subfamily | Dopamine |
Partner Subtype | D2 |
Partner Name | D2R |
Evidence | Experiment |
Annotations | Regulated association of CB1R and D2R alters CB1R signaling. When both Gi/o-coupled CB1R and D2R are coexpexpressed, CB1R stimulation increase cAMP density. Sequential BRET-FRET (SRET) analysis identified the complexes of CB1R, D2R and A2AR in living cells. |
Articles | 15710746, 18587404 |
Methods | BRET, FRET, sequential BRET-FRET (SRET) Radioligand binding, Measurement of cAMP accumulation, Immunoprecipitation, Western Immunoblotting, Immunocytochemistry Staining and Fluorescent Imaging, Measurement of ERK phosphorylation |
Target | NP_057167.2 |
Other Partners | - |
Disease | - |
Interface | - |
Mutation Information | |
Experimentaly Information | |
Predicted Information |