144
GRIP ID 144
Main Title Information about hetero oligomer between CB1 cannabinoid receptor (CB1R) and D2 dopamine receptor (D2R), and interfaces of CB1R
GPCR Class A
GPCR Subfamily Cannabinoid
GPCR Subtype CB1
GPCR Name CB1R
Partner Class A
Partner Subfamily Dopamine
Partner Subtype D2
Partner Name D2R
Evidence Experiment
Annotations Regulated association of CB1R and D2R alters CB1R signaling. When both Gi/o-coupled CB1R and D2R are coexpexpressed, CB1R stimulation increase cAMP density.
Sequential BRET-FRET (SRET) analysis identified the complexes of CB1R, D2R and A2AR in living cells.
Articles 15710746, 18587404
Methods BRET, FRET, sequential BRET-FRET (SRET)
Radioligand binding, Measurement of cAMP accumulation, Immunoprecipitation, Western Immunoblotting, Immunocytochemistry Staining and Fluorescent Imaging, Measurement of ERK phosphorylation
Target NP_057167.2
Mutation Information
Experimentaly Information
Predicted Information