| 145 | |
| GRIP ID | 145 |
| Main Title | Information about hetero oligomer between D2 dopamine receptor (D2R) and CB1 cannabinoid receptor (CB1R), and interfaces of D2R |
| GPCR Class | A |
| GPCR Subfamily | Dopamine |
| GPCR Subtype | D2 |
| GPCR Name | D2R |
| Partner Class | A |
| Partner Subfamily | Cannabinoid |
| Partner Subtype | CB1 |
| Partner Name | CB1R |
| Evidence | Experiment |
| Annotations | Regulated association of CB1R and D2R alters CB1R signaling. When both Gi/o-coupled CB1R and D2R are coexpexpressed, CB1R stimulation increase cAMP density. Sequential BRET-FRET (SRET) analysis identified the complexes of CB1R, D2R and A2AR in living cells. |
| Articles | 15710746, 18587404 |
| Methods | BRET, FRET, sequential BRET-FRET (SRET) Radioligand binding, Measurement of cAMP accumulation, Immunoprecipitation, Western Immunoblotting, Immunocytochemistry Staining and Fluorescent Imaging, Measurement of ERK phosphorylation |
| Target | NP_000786.1 |
| Other Partners | - |
| Disease | - |
| Interface | - |
| Mutation Information | Mutation Information |
| Experimentaly Information | |
| Predicted Information | |