186 |
GRIP ID |
186 |
Main Title |
Information about hetero oligomer between beta 2 adrenergic receptor (beta2AR) and EP1 prostaglandin receptor (EP1R), and interfaces of beta 2AR |
GPCR Class |
A |
GPCR Subfamily |
Adrenergic |
GPCR Subtype |
beta2 |
GPCR Name |
beta2AR |
Partner Class |
A |
Partner Subfamily |
Prostaglandin |
Partner Subtype |
EP1 |
Partner Name |
EP1R |
Evidence |
Experiment |
Annotations |
Activation of EP1 reduced beta2AR-stimulated cAMP in ASM but did not promote or augment beta2AR phosphorylation or alter beta2AR trafficking. BRET shows EP1R and beta2AR forms heterodimers, which are modified by EP1 agonist. In cell membrane [35S]GTPgammaS binding studies, the presence of the EP1 component of the dimer uncoupled beta2AR from Galphas, an effect accentuated by EP1 agonist activation. |
Articles |
16670773 |
Methods |
BRET, 35SGTPgammaS binding study |
Target |
NP_000015.1 |
Other Partners |
- |
Disease |
- |
Interface |
- |
Mutation Information |
Mutation Information |
Experimentaly Information |
|
Predicted Information |
|