| 188 | |
| GRIP ID | 188 |
| Main Title | Information about hetero oligomer between opioid receptor ( OPR) and CXCR4 chemokine receptor, and interfaces of OPR |
| GPCR Class | A |
| GPCR Subfamily | Opioid |
| GPCR Subtype | kappa |
| GPCR Name | kappaOPR |
| Partner Class | A |
| Partner Subfamily | Chemokine |
| Partner Subtype | CXCR4 |
| Partner Name | CXCR4 |
| Evidence | Experiment |
| Annotations | Both mu and delta ORs cross-desensitize CCR1, CCR2, CCR5, but not CXCR4, while kappa OR is able to cross-desensitize CXCR4, and this phenomenon is bi-directional. Chemotactic responses by kappa OR activation are reduced by activation of CXCR4 in advance. In addition, calcium mobilization assays show these cross-desensitization processes occur within seconds of receptor activation, and target receptor internalization is not responsible for desensitization between these receptors. |
| Articles | 18533278 |
| Methods | Calcium mobilization assay |
| Target | NP_000903.2 |
| Other Partners | - |
| Disease | - |
| Interface | - |
| Mutation Information | |
| Experimentaly Information | |
| Predicted Information | |