| 19 | |
| GRIP ID | 19 |
| Main Title | Information about hetero oligomer between A2a adenosine receptor (A2aR) and D2 dopamine receptor (D2R) and interfaces of A2aR |
| GPCR Class | A |
| GPCR Subfamily | Adenosine |
| GPCR Subtype | A2a |
| GPCR Name | A2aR |
| Partner Class | A |
| Partner Subfamily | Dopamine |
| Partner Subtype | D2 |
| Partner Name | D2R |
| Evidence | Experiment |
| Annotations | D2R and A2AR forms hetero complexes. Long term exposure of the hetero complexes to their agonists in D2R-cotransfected SH-SY5Y cells results in coaggregation, cointernalization and codesensitization of the hetero complexes. This might lead to the treatment of Parkinson's disease and schizophrenia, in which D2R are involved. |
| Articles | 11872740 |
| Methods | Immunolabeling, Coimmunoprecipitation |
| Target | NP_000666.2 |
| Other Partners | - |
| Disease | - |
| Interface | - |
| Mutation Information | Mutation Information |
| Experimentaly Information | |
| Predicted Information | |