213
GRIP ID 213
Main Title Information about hetero oligomer between opioid receptor ( OPR) and receptor transport protein 4 (RTP4), and interfaces of OPR
GPCR Class A
GPCR Subfamily Opioid
GPCR Subtype mu
GPCR Name muOPR
Partner Class O
Partner Subfamily Receptor transport protein
Partner Subtype RTP4
Partner Name RTP4
Evidence Experiment
Annotations Association with RTP4, which is known as a Golgi chaperone, protects mu and delta ORs from ubiquitination and degradation. As a result, the amount of hetero dimers on the surface decreases, which affects cellular signaling. In this way, the oligomeric organization of opioid receptors is controlled by RTP4, which governs their membrane targeting and functional activity.
Articles 18836069
Methods ELISA, immunoblotting, coimmunoprecipitation, western blotting, SEAP assay
Target NP_000905.3
Mutation Information
Experimentaly Information
Predicted Information