213 |
GRIP ID |
213 |
Main Title |
Information about hetero oligomer between opioid receptor ( OPR) and receptor transport protein 4 (RTP4), and interfaces of OPR |
GPCR Class |
A |
GPCR Subfamily |
Opioid |
GPCR Subtype |
mu |
GPCR Name |
muOPR |
Partner Class |
O |
Partner Subfamily |
Receptor transport protein |
Partner Subtype |
RTP4 |
Partner Name |
RTP4 |
Evidence |
Experiment |
Annotations |
Association with RTP4, which is known as a Golgi chaperone, protects mu and delta ORs from ubiquitination and degradation. As a result, the amount of hetero dimers on the surface decreases, which affects cellular signaling. In this way, the oligomeric organization of opioid receptors is controlled by RTP4, which governs their membrane targeting and functional activity. |
Articles |
18836069 |
Methods |
ELISA, immunoblotting, coimmunoprecipitation, western blotting, SEAP assay |
Target |
NP_000905.3 |
Other Partners |
- |
Disease |
- |
Interface |
- |
Mutation Information |
|
Experimentaly Information |
|
Predicted Information |
|