214 |
GRIP ID |
214 |
Main Title |
Information about hetero oligomer between receptor transport protein 4 (RTP4) and opioid receptor ( OPR), and interfaces of RT4R |
GPCR Class |
O |
GPCR Subfamily |
Receptor transport protein |
GPCR Subtype |
RTP4 |
GPCR Name |
RTP4 |
Partner Class |
A |
Partner Subfamily |
Opioid |
Partner Subtype |
mu |
Partner Name |
muOPR |
Evidence |
Experiment |
Annotations |
Association with RTP4, which is known as a Golgi chaperone, protects mu and delta ORs from ubiquitination and degradation. As a result, the amount of hetero dimers on the surface decreases, which affects cellular signaling. In this way, the oligomeric organization of opioid receptors is controlled by RTP4, which governs their membrane targeting and functional activity. |
Articles |
18836069 |
Methods |
ELISA, Immunoblotting, Coimmunoprecipitation, Western blotting, SEAP assay |
Target |
NP_000905.3 |
Other Partners |
- |
Disease |
- |
Interface |
- |
Mutation Information |
|
Experimentaly Information |
|
Predicted Information |
|