28
GRIP ID 28
Main Title Information about hetero oligomer between A2a adenosine receptor (A2aR) and metabotropic glutamate receptor type 5 (mGluR5) and interfaces of A2aR
GPCR Class A
GPCR Subfamily Adenosine
GPCR Subtype A2a
GPCR Name A2aR
Partner Class C
Partner Subfamily Metabotropic Glutamate
Partner Subtype Type 5
Partner Name mGluR5
Evidence Experiment
Annotations Transiently cotransfected A2AR and mGluR5 were colocalzed in nonpermeabilized human HEK293 cells by confocal laser microscopy. A2AR and mGluR5 complexes were observed by Western blotting of immunoprecipitates of either Flag-A2AR or hemagglutinin-mGluR5 in membrane preparations from cotransfected HEK-293 cells and of native A2AR and mGluR5 in rat striatal membrane preparations. In cotransfected HEK-293 cells, a synergistic effect on extracellular signal-regulated kinase 1/2 phosphorylation and c-fos expression was demonstrated upon A2AR/mGluR5 costimulation.
Articles 12189203
Methods Coimmunoprecipitation
Target NP_000666.2
Mutation Information Mutation Information
Experimentaly Information
Predicted Information