35 |
GRIP ID |
35 |
Main Title |
Information about hetero oligomer between 1a and 2a adrenergic receptors ( 1aAR- 2aAR) and interfaces of 1aAR |
GPCR Class |
A |
GPCR Subfamily |
Adrenergic |
GPCR Subtype |
beta1 |
GPCR Name |
beta1AR |
Partner Class |
A |
Partner Subfamily |
Adrenergic |
Partner Subtype |
alpha2a |
Partner Name |
alpha2aAR |
Evidence |
Experiment |
Annotations |
beta1AR and alpha2aAR form robust hetero dimer in HEK-293 cells. An interaction between beta1AR and alpha2aAR is regulated by glycosylation. The interaction may play a key role in cross-talk and mutual regulation between these receptors. |
Articles |
12529373 |
Methods |
Western Blotting, Coimmunoprecipitation, Immunofluorescence confocal microscopy |
Target |
NP_000675.1 |
Other Partners |
- |
Disease |
- |
Interface |
- |
Mutation Information |
|
Experimentaly Information |
|
Predicted Information |
|