| 41 | |
| GRIP ID | 41 |
| Main Title | Information about hetero oligomer between opioid receptor ( OPR) and 2 adrenergic receptor ( 2AR) and interfaces of OPR |
| GPCR Class | A |
| GPCR Subfamily | Opioid |
| GPCR Subtype | delta |
| GPCR Name | deltaOPR |
| Partner Class | A |
| Partner Subfamily | Adrenergic |
| Partner Subtype | beta2 |
| Partner Name | beta2AR |
| Evidence | Experiment |
| Annotations | Coexpression of deltaOR with beta2AR undergoes isoproterenol-mediated endocytosis. beta2AR in the same cell undergoes etorphine-mediated endocytosis. Coexpression of beta2AR with kappaOR undergoes neither opioid- nor isoproterenol-mediated endocytosis. In addition, these cells show a substantial decrease in the isoproterenol-induced phosphorylation of MAPK. These results provide the evidence of GPCR hetero oligomerization that couple to different types of trimeric G-proteins, which leads to the modification of receptor trafficking as well as signal transduction. |
| Articles | 11134510 |
| Methods | Coimmunoprecipitation, Western blot |
| Target | NP_000902.3 |
| Other Partners | - |
| Disease | - |
| Interface | - |
| Mutation Information | |
| Experimentaly Information | |
| Predicted Information | |