59
GRIP ID 59
Main Title Information about homo oligomer of CCR5 chemokine receptor (CCR5) and interfaces of CCR5
GPCR Class A
GPCR Subfamily Chemokine
GPCR Subtype CCR5
GPCR Name CCR5
Partner Class A
Partner Subfamily Chemokine
Partner Subtype CCR5
Partner Name CCR5
Evidence Experiment
Annotations Anti-CCR5 mAb efficiently prevents HIV-1 infection by inducing receptor dimerization. Chemokine receptor dimerization also is induced by chemokines and is required for their anti-HIV-1 activity.
Articles 11854425, 14716309, 10725362, 12089144
Methods Point mutation, bioinformatics approach
BRET
Western blot
Cross-linking in the presence of agonist, immunoprecipitation, western blot
Target NP_000570.1
Mutation Information
Experimentaly Information Experiment Information
Predicted Information