59 | |
GRIP ID | 59 |
Main Title | Information about homo oligomer of CCR5 chemokine receptor (CCR5) and interfaces of CCR5 |
GPCR Class | A |
GPCR Subfamily | Chemokine |
GPCR Subtype | CCR5 |
GPCR Name | CCR5 |
Partner Class | A |
Partner Subfamily | Chemokine |
Partner Subtype | CCR5 |
Partner Name | CCR5 |
Evidence | Experiment |
Annotations | Anti-CCR5 mAb efficiently prevents HIV-1 infection by inducing receptor dimerization. Chemokine receptor dimerization also is induced by chemokines and is required for their anti-HIV-1 activity. |
Articles | 11854425, 14716309, 10725362, 12089144 |
Methods | Point mutation, bioinformatics approach BRET Western blot Cross-linking in the presence of agonist, immunoprecipitation, western blot |
Target | NP_000570.1 |
Other Partners | - |
Disease | - |
Interface | - |
Mutation Information | |
Experimentaly Information | Experiment Information |
Predicted Information |