| H00026 | |
| H number | H00026 |
| Name | Endometrial cancer |
| Description | Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification. |
| Category | Cancer DIS_PATHWAY hsa05213 Endometrial cancer |
| Network | nt06271 Endometrial cancer |
| Gene | ERBB2 (amplification) [HSA:2064] [KO:K05083] PTEN (mutation, deletions, methylation) [HSA:5728] [KO:K01110] MLH1 (mutation, methylation) [HSA:4292] [KO:K08734] KRAS [HSA:3845] [KO:K07827] CTNNB1 [HSA:1499] [KO:K02105] TP53 [HSA:7157] [KO:K04451] MSH3 [HSA:4437] [KO:K08736] CDH1 [HSA:999] [KO:K05689] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Medroxyprogesterone acetate [DR:D00951] Lenvatinib mesylate [DR:D09920] Pembrolizumab [DR:D10574] (MSI-H or dMMR) Dostarlimab [DR:D11366] |
| Comment | - |
| Other DBs | ICD-11: 2C76 ICD-10: C54 MeSH: D016889 OMIM: 608089 |
| Reference | PMID:17028294 AUTHORS Hecht JL, Mutter GL. TITLE Molecular and pathologic aspects of endometrial carcinogenesis. JOURNAL J Clin Oncol 24:4783-91 (2006) DOI:10.1200/JCO.2006.06.7173 PMID:15947972 AUTHORS Ryan AJ, Susil B, Jobling TW, Oehler MK. TITLE Endometrial cancer. JOURNAL Cell Tissue Res 322:53-61 (2005) DOI:10.1007/s00441-005-1109-5 PMID:12583434 AUTHORS Salvesen HB, Akslen LA. TITLE Molecular pathogenesis and prognostic factors in endometrial carcinoma. JOURNAL APMIS 110:673-89 (2002) DOI:10.1034/j.1600-0463.2002.1101001.x PMID:16508724 AUTHORS Shiozawa T, Konishi I. TITLE Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment. JOURNAL Int J Clin Oncol 11:13-21 (2006) DOI:10.1007/s10147-005-0546-1 PMID:8782829 (MSH3) AUTHORS Risinger JI, Umar A, Boyd J, Berchuck A, Kunkel TA, Barrett JC TITLE Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. JOURNAL Nat Genet 14:102-5 (1996) DOI:10.1038/ng0996-102 PMID:8075649 (CDH1) AUTHORS Risinger JI, Berchuck A, Kohler MF, Boyd J TITLE Mutations of the E-cadherin gene in human gynecologic cancers. JOURNAL Nat Genet 7:98-102 (1994) DOI:10.1038/ng0594-98 |