H00054 | |
H number | H00054 |
Name | Nasopharyngeal cancer |
Description | Nasopharyngeal carcinoma (NPC) is a rare disease in most parts of the world, with an age-standardised annual incidence of less than 1 per 100000. However, in Southern China, parts of Southeast Asia and the Mediterranean basin, NPC is an endemic disease with an incidence of 10-30 per 100000. Genome-wide studies have unravelled multiple chromosomal abnormalities with involvement of specific oncogenes and tumor suppressor genes. Alterations of genes such as Ras association domain family 1A (RASSF1A), p16/INK4A, p14/ARF suggest that multiple cellular pathways were dysregulated in the NPC cells. Studies on the precancerous lesions revealed early genetic changes and a critical role of Epstein- Barr virus (EBV) latent infection in the development of this cancer. |
Category | Cancer |
Network | - |
Gene | (NPCA3) MST1R [HSA:4486] [KO:K05100] RASSF1 (promoter hypermethylation) [HSA:11186] [KO:K09850] CDKN2A (promoter hypermethylation) [HSA:1029] [KO:K06621] BCL2 (overexpression) [HSA:596] [KO:K02161] EDNRB (promoter hypermethylation) [HSA:1910] [KO:K04198] CADM1 (promoter hypermethylation) [HSA:23705] [KO:K06781] CDH1 (decreased expression) [HSA:999] [KO:K05689] |
Pathogen | Human herpesvirus 4 (Epstein-Barr virus) [GN:T40079] |
Env factor | - |
Carcinogen | - |
Drug | - |
Comment | - |
Other DBs | ICD-11: 2B6B ICD-10: C11 MeSH: D009303 OMIM: 617075 |
Reference | PMID:26951679 (NPCA3) AUTHORS Dai W, Zheng H, Cheung AK, Tang CS, Ko JM, Wong BW, Leong MM, Sham PC, Cheung F, Kwong DL, Ngan RK, Ng WT, Yau CC, Pan J, Peng X, Tung S, Zhang Z, Ji M, Chiang AK, Lee AW, Lee VH, Lam KO, Au KH, Cheng HC, Yiu HH, Lung ML TITLE Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma. JOURNAL Proc Natl Acad Sci U S A 113:3317-22 (2016) DOI:10.1073/pnas.1523436113 PMID:12450731 (GENE) AUTHORS Lo KW, Huang DP. TITLE Genetic and epigenetic changes in nasopharyngeal carcinoma. JOURNAL Semin Cancer Biol 12:451-62 (2002) DOI:10.1016/S1044579X02000883 PMID:15958470 AUTHORS Chan AT TITLE Head and neck cancer: treatment of nasopharyngeal cancer. JOURNAL Ann Oncol 16 Suppl 2:ii265-8 (2005) DOI:10.1093/annonc/mdi732 PMID:15510157 AUTHORS Young LS, Rickinson AB. TITLE Epstein-Barr virus: 40 years on. JOURNAL Nat Rev Cancer 4:757-68 (2004) DOI:10.1038/nrc1452 |