| H00357 | |
| H number | H00357 |
| Name | African trypanosomiasis; Sleeping sickness |
| Description | African trypanosomiasis is a parasitic disease affecting both humans and livestock. It is one of the most common serious protozoan infections in sub-Saharan Africa, especially in areas of conflict. Its causative agent is Trypanosoma brucei, whose protein has been shown to induce apoptosis in human brain. |
| Category | Parasitic infectious disease DIS_PATHWAY hsa05143 African trypanosomiasis |
| Network | - |
| Gene | - |
| Pathogen | Trypanosoma brucei [GN:tbr tbg] |
| Env factor | - |
| Carcinogen | - |
| Drug | Fexinidazole [DR:D11252] |
| Comment | Vector: Glossina pallidipes (tsetse fly) |
| Other DBs | ICD-11: 1F51 ICD-10: B56 MeSH: D014353 MedlinePlus: 001362 |
| Reference | PMID:19707588 AUTHORS Hotez PJ, Kamath A TITLE Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden. JOURNAL PLoS Negl Trop Dis 3:e412 (2009) DOI:10.1371/journal.pntd.0000412 PMID:14698435 AUTHORS Stiles JK, Whittaker J, Sarfo BY, Thompson WE, Powell MD, Bond VC TITLE Trypanosome apoptotic factor mediates apoptosis in human brain vascular endothelial cells. JOURNAL Mol Biochem Parasitol 133:229-40 (2004) DOI:10.1016/j.molbiopara.2003.10.011 |