| H00358 | |
| H number | H00358 |
| Name | Chagas disease; American trypanosomiasis |
| Description | Chagas disease, also known as American trypanosomiasis, is caused by infection with protozoan parasite Trypanosoma cruzi. The infection is transmitted by hematophagous reduviid insect vectors through fecal contamination. The majority of infected individuals live in Latin American countries. Chagas disease is characterized by an acute phase followed by a chronic phase, with sustained inflammation that causes cardiomyopathy, digestive disorders, and neuropathies. |
| Category | Parasitic infectious disease DIS_PATHWAY hsa05142 Chagas disease |
| Network | - |
| Gene | - |
| Pathogen | Trypanosoma cruzi [GN:tcr] |
| Env factor | - |
| Carcinogen | - |
| Drug | Nifurtimox [DR:D00833] |
| Comment | Vector: Rhodnius prolixus (Reduviid bug) |
| Other DBs | ICD-11: 1F53 ICD-10: B57 MeSH: D014355 MedlinePlus: 001372 |
| Reference | PMID:26222561 AUTHORS Bern C TITLE Chagas' Disease. JOURNAL N Engl J Med 373:456-66 (2015) DOI:10.1056/NEJMra1410150 PMID:31006555 AUTHORS Guarner J TITLE Chagas disease as example of a reemerging parasite. JOURNAL Semin Diagn Pathol 36:164-169 (2019) DOI:10.1053/j.semdp.2019.04.008 |