| H00721 | |
| H number | H00721 |
| Name | Pyogenic bacterial infections, recurrent, due to MYD88 deficiency |
| Description | Autosomal recessive MyD88 deficiency predisposes affected patients to recurrent pyogenic bacterial infections, including invasive pneumococcal disease. The patients are resistant to other microbes. |
| Category | Immune system disease |
| Network | - |
| Gene | MYD88 [HSA:4615] [KO:K04729] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: 4A00.2 MeSH: C567379 OMIM: 612260 |
| Reference | PMID:18669862 AUTHORS von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Arostegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yague J, Anton J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Marodi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, Casanova JL TITLE Pyogenic bacterial infections in humans with MyD88 deficiency. JOURNAL Science 321:691-6 (2008) DOI:10.1126/science.1158298 PMID:21734245 AUTHORS Picard C, Casanova JL, Puel A TITLE Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IkappaBalpha deficiency. JOURNAL Clin Microbiol Rev 24:490-7 (2011) DOI:10.1128/CMR.00001-11 PMID:20236864 AUTHORS Bousfiha A, Picard C, Boisson-Dupuis S, Zhang SY, Bustamante J, Puel A, Jouanguy E, Ailal F, El-Baghdadi J, Abel L, Casanova JL TITLE Primary immunodeficiencies of protective immunity to primary infections. JOURNAL Clin Immunol 135:204-9 (2010) DOI:10.1016/j.clim.2010.02.001 |