H00864 | |
H number | H00864 |
Name | Trichotillomania |
Description | Trichotillomania (TTM) is a chronic behavioral disorder characterized by the irresistible urge to pull out one's hair, resulting in noticeable hair loss. Mutations in SLITRK1 are found in patients with TTM. |
Category | Mental and behavioural disorder |
Network | - |
Gene | SLITRK1 [HSA:114798] [KO:K25832] |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | - |
Comment | Mutations in SLITRK1 are also found in patients with Tourette syndrome. [DS:H00862] |
Other DBs | ICD-11: 6B25.0 ICD-10: F63.3 MeSH: D014256 OMIM: 613229 |
Reference | PMID:17003809 AUTHORS Zuchner S, Cuccaro ML, Tran-Viet KN, Cope H, Krishnan RR, Pericak-Vance MA, Wright HH, Ashley-Koch A TITLE SLITRK1 mutations in trichotillomania. JOURNAL Mol Psychiatry 11:887-9 (2006) DOI:10.1038/sj.mp.4001865 PMID:18794888 AUTHORS Katayama K, Yamada K, Ornthanalai VG, Inoue T, Ota M, Murphy NP, Aruga J TITLE Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities. JOURNAL Mol Psychiatry 15:177-84 (2010) DOI:10.1038/mp.2008.97 |