H00887 | |
H number | H00887 |
Name | Lipoprotein glomerulopathy |
Description | Lipoprotein glomerulopathy is a rare hereditary disorder characterized by disturbed remnant lipoprotein catabolism and intravascular glomerular deposition of lipoprotein-containing thrombi. Patients usually present with proteinuria and hypertension, microhematuria is rare, and renal function becomes impaired. Rare mutations in apolipoprotein E (apoE) gene may contribute to the pathogenesis of the disease. |
Category | Inherited metabolic disorder |
Network | - |
Gene | APOE [HSA:348] [KO:K04524] |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | - |
Comment | - |
Other DBs | ICD-11: MF82 MeSH: C567089 OMIM: 611771 |
Reference | PMID:21464714 AUTHORS Tsimihodimos V, Elisaf M TITLE Lipoprotein glomerulopathy. JOURNAL Curr Opin Lipidol 22:262-9 (2011) DOI:10.1097/MOL.0b013e328345ebb0 PMID:16490634 AUTHORS Sam R, Wu H, Yue L, Mazzone T, Schwartz MM, Arruda JA, Dunea G, Singh AK TITLE Lipoprotein glomerulopathy: a new apolipoprotein E mutation with enhanced glomerular binding. JOURNAL Am J Kidney Dis 47:539-48 (2006) DOI:10.1053/j.ajkd.2005.12.031 PMID:16431249 AUTHORS Saito T, Matsunaga A, Oikawa S TITLE Impact of lipoprotein glomerulopathy on the relationship between lipids and renal diseases. JOURNAL Am J Kidney Dis 47:199-211 (2006) DOI:10.1053/j.ajkd.2005.10.017 |