| H00967 | |
| H number | H00967 |
| Name | Adiponectin deficiency |
| Description | Adiponectin is a major adipocyte-derived protein with insulin-sensitizing, anti-inflammatory and anti-atherogenic properties. Adiponectin deficiency related to several obesity related malignancies including colorectal cancer. |
| Category | Inherited metabolic disorder |
| Network | - |
| Gene | ADIPOQ [HSA:9370] [KO:K07296] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: 5C5Y MeSH: C567258 OMIM: 612556 |
| Reference | PMID:22198319 AUTHORS Saxena A, Chumanevich A, Fletcher E, Larsen B, Lattwein K, Kaur K, Fayad R TITLE Adiponectin deficiency: role in chronic inflammation induced colon cancer. JOURNAL Biochim Biophys Acta 1822:527-36 (2012) DOI:10.1016/j.bbadis.2011.12.006 PMID:12802337 AUTHORS Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T TITLE Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. JOURNAL Nature 423:762-9 (2003) DOI:10.1038/nature01705 PMID:12032136 AUTHORS Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J, Eto K, Yamashita T, Kamon J, Satoh H, Yano W, Froguel P, Nagai R, Kimura S, Kadowaki T, Noda T TITLE Disruption of adiponectin causes insulin resistance and neointimal formation. JOURNAL J Biol Chem 277:25863-6 (2002) DOI:10.1074/jbc.C200251200 PMID:12431986 AUTHORS Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, Uchida S, Ito Y, Takakuwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami K, Ohnishi Y, Naitoh T, Yamamura K, Ueyama Y, Froguel P, Kimura S, Nagai R, Kadowaki T TITLE Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. JOURNAL J Biol Chem 278:2461-8 (2003) DOI:10.1074/jbc.M209033200 |