H01043 | |
H number | H01043 |
Name | Onchocerciasis; River blindness; Robles disease |
Description | Human onchocerciasis is an infection caused by the filarial nematode Onchocerca volvulus transmitted by Simulium blackflies. The disease is endemic in sub-Saharan African countries, the Arabian peninsula, and small parts of Latin America. Persons with onchocerciasis may develop skin diseases such as pruritus, lichenification, and depigmentation, as well as ocular manifestations. Onchocerca volvulus contain Wolbachia bacteria as mutualistic symbionts, and these Wolbachia affects the nematode survival. |
Category | Parasitic infectious disease |
Network | - |
Gene | - |
Pathogen | Onchocerca volvulus |
Env factor | - |
Carcinogen | - |
Drug | Ivermectin [DR:D00804] Moxidectin [DR:D05084] |
Comment | Vector: Simulium blackflies |
Other DBs | ICD-11: 1F6A ICD-10: B73 MeSH: D009855 |
Reference | PMID:20739055 AUTHORS Taylor MJ, Hoerauf A, Bockarie M TITLE Lymphatic filariasis and onchocerciasis. JOURNAL Lancet 376:1175-85 (2010) DOI:10.1016/S0140-6736(10)60586-7 PMID:20801094 AUTHORS Cupp EW, Sauerbrey M, Richards F TITLE Elimination of human onchocerciasis: history of progress and current feasibility using ivermectin (Mectizan((R))) monotherapy. JOURNAL Acta Trop 120 Suppl 1:S100-8 (2011) DOI:10.1016/j.actatropica.2010.08.009 PMID:21734243 AUTHORS Tamarozzi F, Halliday A, Gentil K, Hoerauf A, Pearlman E, Taylor MJ TITLE Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment. JOURNAL Clin Microbiol Rev 24:459-68 (2011) DOI:10.1128/CMR.00057-10 |