| H01048 | |
| H number | H01048 |
| Name | Liver fluke disease; Fascioliasis |
| Description | Fascioliasis is a foodborne zoonotic disease caused by the liver flukes Fasciola hepatica and Fasciola gigantica. Whereas in Europe, the Americas and Oceania only F. hepatica is concerned, the distributions of both species overlap in many areas of Africa and Asia. An infection is accomplished through oral ingestion of the infective stage of the parasite either through consumption of uncooked or unwashed aquatic plants, or through drinking contaminated water. The presence of F. hepatica flukes in humans was first documented in 1760. |
| Category | Parasitic infectious disease |
| Network | - |
| Gene | - |
| Pathogen | Fasciola hepatica Fasciola gigantica |
| Env factor | - |
| Carcinogen | - |
| Drug | Triclabendazole [DR:D07364] |
| Comment | Intermediate host: freshwater snail species of the family Lymnaeidae |
| Other DBs | ICD-11: 1F82 ICD-10: B66.3 MeSH: D005211 |
| Reference | PMID:18725803 AUTHORS Marcos LA, Terashima A, Gotuzzo E TITLE Update on hepatobiliary flukes: fascioliasis, opisthorchiasis and clonorchiasis. JOURNAL Curr Opin Infect Dis 21:523-30 (2008) DOI:10.1097/QCO.0b013e32830f9818 PMID:16307491 AUTHORS Keiser J, Engels D, Buscher G, Utzinger J TITLE Triclabendazole for the treatment of fascioliasis and paragonimiasis. JOURNAL Expert Opin Investig Drugs 14:1513-26 (2005) DOI:10.1517/13543784.14.12.1513 PMID:16150452 AUTHORS Mas-Coma S, Bargues MD, Valero MA TITLE Fascioliasis and other plant-borne trematode zoonoses. JOURNAL Int J Parasitol 35:1255-78 (2005) DOI:10.1016/j.ijpara.2005.07.010 PMID:19597009 AUTHORS Keiser J, Utzinger J TITLE Food-borne trematodiases. JOURNAL Clin Microbiol Rev 22:466-83 (2009) DOI:10.1128/CMR.00012-09 |