H01102 | |
H number | H01102 |
Name | Pituitary adenomas |
Description | Pituitary adenomas are an important and frequently occurring form of intracranial tumor. They are usually benign but can give rise to severe clinical syndromes due to hormonal excess, or to visual/cranial disturbances due to mass effect. The tumor can be clinically nonfunctioning or hormone secreting. Among the latter, prolactin (PRL) and growth hormone (GH)-secreting adenomas are the most common. The majority of pituitary adenomas arise sporadically, although a subset occurs as component tumors of well-characterized familial cancer syndromes, such as multiple endocrine neoplasia type 1 (MEN1), Carney complex (CNC), and MEN1-like syndrome (MEN4). |
Category | Neoplasm |
Network | nt06310(H01102) CRH-ACTH-cortisol signaling |
Gene | (MEN1) MEN1 [HSA:4221] [KO:K14970] (MEN4) CDKN1B [HSA:1027] [KO:K06624] (CNC) PRKAR1A [HSA:5573] [KO:K04739] (PITA1) AIP [HSA:9049] [KO:K17767] (PITA2) GPR101 [HSA:83550] [KO:K08423] (PITA3) GNAS [HSA:2778] [KO:K04632] (PITA4) USP8 [HSA:9101] [KO:K11839] (PITA5) CDH23 [HSA:64072] [KO:K06813] RASD1 [HSA:51655] [KO:K07843] |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | Omeprazole [DR:D00455] |
Comment | - |
Other DBs | ICD-11: 2F37.0 ICD-10: D44.8 MeSH: D010911 OMIM: 600634 610755 160980 102200 300943 617686 219090 617540 |
Reference | PMID:19522822 AUTHORS Tichomirowa MA, Daly AF, Beckers A TITLE Familial pituitary adenomas. JOURNAL J Intern Med 266:5-18 (2009) DOI:10.1111/j.1365-2796.2009.02109.x PMID:27588171 AUTHORS Xiong Q, Ge W TITLE Gene mutations in Cushing's disease. JOURNAL Biomed Rep 5:277-282 (2016) DOI:10.3892/br.2016.729 PMID:27742789 AUTHORS Caimari F, Korbonits M TITLE Novel Genetic Causes of Pituitary Adenomas. JOURNAL Clin Cancer Res 22:5030-5042 (2016) DOI:10.1158/1078-0432.CCR-16-0452 PMID:9103196 (MEN1) AUTHORS Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, Heppner C, Dong Q, Spiegel AM, Burns AL, Marx SJ TITLE Positional cloning of the gene for multiple endocrine neoplasia-type 1. JOURNAL Science 276:404-7 (1997) DOI:10.1126/science.276.5311.404 PMID:17030811 (CDKN1B) AUTHORS Pellegata NS, Quintanilla-Martinez L, Siggelkow H, Samson E, Bink K, Hofler H, Fend F, Graw J, Atkinson MJ TITLE Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. JOURNAL Proc Natl Acad Sci U S A 103:15558-63 (2006) DOI:10.1073/pnas.0603877103 PMID:10973256 (PRKAR1A) AUTHORS Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS, Cho-Chung YS, Stratakis CA TITLE Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. JOURNAL Nat Genet 26:89-92 (2000) DOI:10.1038/79238 PMID:16728643 (AIP) AUTHORS Vierimaa O, Georgitsi M, Lehtonen R, Vahteristo P, Kokko A, Raitila A, Tuppurainen K, Ebeling TM, Salmela PI, Paschke R, Gundogdu S, De Menis E, Makinen MJ, Launonen V, Karhu A, Aaltonen LA TITLE Pituitary adenoma predisposition caused by germline mutations in the AIP gene. JOURNAL Science 312:1228-30 (2006) DOI:10.1126/science.1126100 PMID:25470569 (GPR101) AUTHORS Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra Mde L, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenicky P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA TITLE Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. JOURNAL N Engl J Med 371:2363-74 (2014) DOI:10.1056/NEJMoa1408028 PMID:7737262 (GNAS) AUTHORS Williamson EA, Ince PG, Harrison D, Kendall-Taylor P, Harris PE TITLE G-protein mutations in human pituitary adrenocorticotrophic hormone-secreting adenomas. JOURNAL Eur J Clin Invest 25:128-31 (1995) DOI:10.1111/j.1365-2362.1995.tb01537.x PMID:25485838 (USP8) AUTHORS Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M, Komada M TITLE Mutations in the deubiquitinase gene USP8 cause Cushing's disease. JOURNAL Nat Genet 47:31-8 (2015) DOI:10.1038/ng.3166 PMID:28413019 (CDH23) AUTHORS Zhang Q, Peng C, Song J, Zhang Y, Chen J, Song Z, Shou X, Ma Z, Peng H, Jian X, He W, Ye Z, Li Z, Wang Y, Ye H, Zhang Z, Shen M, Tang F, Chen H, Shi Z, Chen C, Chen Z, Shen Y, Wang Y, Lu S, Zhang J, Li Y, Li S, Mao Y, Zhou L, Yan H, Shi Y, Huang C, Zhao Y TITLE Germline Mutations in CDH23, Encoding Cadherin-Related 23, Are Associated with Both Familial and Sporadic Pituitary Adenomas. JOURNAL Am J Hum Genet 100:817-823 (2017) DOI:10.1016/j.ajhg.2017.03.011 PMID:28487882 (RASD1) AUTHORS Uzilov AV, Cheesman KC, Fink MY, Newman LC, Pandya C, Lalazar Y, Hefti M, Fowkes M, Deikus G, Lau CY, Moe AS, Kinoshita Y, Kasai Y, Zweig M, Gupta A, Starcevic D, Mahajan M, Schadt EE, Post KD, Donovan MJ, Sebra R, Chen R, Geer EB TITLE Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma. JOURNAL Cold Spring Harb Mol Case Stud 3:a001602 (2017) DOI:10.1101/mcs.a001602 |