| H01175 | |
| H number | H01175 |
| Name | Staphylococcal infection |
| Description | Staphylococci are widespread as commensals of humans and animals where they colonize the skin or mucous membranes. Firstly, Staphylococcus lugdunensis is a most unusual coagulase-negative staphylococcus found on the human skin. It can cause infections at many sites including superficial skin infections, bacteremia, endocarditis, osteomyelitis, and breast abscess. Endocarditis caused by S. lugdunensis can lead to substantial morbidity and mortality. Secondly, Staphylococcus haemolyticus, found among the normal skin flora, is commonly isolated from the axillae, perineum, and inguinal areas of humans and causes septicemia, peritonitis, otitis, and urinary tract infections. S. haemolyticus is notorious for its multidrug resistance and historically early acquisition of resistance to methicillin and glycopeptide antibiotics. Finally, Staphylococcus pseudintermedius is an important opportunistic pathogen of dogs and cats. S. pseudintermedius colonization is very uncommon in humans. It is rarely isolated from human dog-bite wounds. The infection has been associated with wide range of symptoms such as bacteremia, a brain abscess, and pneumonia. |
| Category | Bacterial infectious disease |
| Network | - |
| Gene | - |
| Pathogen | Staphylococcus lugdunensis [GN:slg sln] Staphylococcus haemolyticus [GN:sha] Staphylococcus pseudintermedius |
| Env factor | - |
| Carcinogen | - |
| Drug | Vancomycin hydrochloride [DR:D00926] Bacitracin [DR:D00128] Clindamycin palmitate hydrochloride [DR:D01990] Clindamycin hydrochloride [DR:D02132] |
| Comment | Treatment was most commonly initiated with vancomycin and narrowed as antibiotic susceptibilities allowed. Methicillin resistance has been reported. |
| Other DBs | ICD-11: 1A10 ICD-10: A41.1 MeSH: D013203 |
| Reference | PMID:21886051 AUTHORS Klotchko A, Wallace MR, Licitra C, Sieger B TITLE Staphylococcus lugdunensis: an emerging pathogen. JOURNAL South Med J 104:509-14 (2011) DOI:10.1097/SMJ.0b013e31821e91b1 PMID:21195974 AUTHORS Liu PY, Huang YF, Tang CW, Chen YY, Hsieh KS, Ger LP, Chen YS, Liu YC TITLE Staphylococcus lugdunensis infective endocarditis: a literature review and analysis of risk factors. JOURNAL J Microbiol Immunol Infect 43:478-84 (2010) DOI:10.1016/S1684-1182(10)60074-6 PMID:20434383 AUTHORS Chopra A, Gulati D, Woldenberg N, Singh M TITLE Intracardiac lead endocarditis due to Staphylococcus lugdunensis. JOURNAL Int J Infect Dis 14 Suppl 3:e291-3 (2010) DOI:10.1016/j.ijid.2009.12.008 PMID:19447659 AUTHORS Pada S, Lye DC, Leo YS, Barkham T TITLE Utility of 16S ribosomal DNA sequencing in the diagnosis of Staphylococcus lugdunensis native valve infective endocarditis: case report and literature review. JOURNAL Int J Infect Dis 13:e511-3 (2009) DOI:10.1016/j.ijid.2009.02.019 PMID:21930571 AUTHORS van Duijkeren E, Catry B, Greko C, Moreno MA, Pomba MC, Pyorala S, Ruzauskas M, Sanders P, Threlfall EJ, Torren-Edo J, Torneke K TITLE Review on methicillin-resistant Staphylococcus pseudintermedius. JOURNAL J Antimicrob Chemother 66:2705-14 (2011) DOI:10.1093/jac/dkr367 PMID:20178486 AUTHORS Fitzgerald JR TITLE The Staphylococcus intermedius group of bacterial pathogens: species re-classification, pathogenesis and the emergence of meticillin resistance. JOURNAL Vet Dermatol 20:490-5 (2009) DOI:10.1111/j.1365-3164.2009.00828.x PMID:19246166 AUTHORS Weese JS, van Duijkeren E TITLE Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in veterinary medicine. JOURNAL Vet Microbiol 140:418-29 (2010) DOI:10.1016/j.vetmic.2009.01.039 PMID:16237012 AUTHORS Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K. TITLE Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species. JOURNAL J Bacteriol 187:7292-308 (2005) DOI:10.1128/JB.187.21.7292-7308.2005 |