| H01191 | |
| H number | H01191 |
| Name | Asthma with nasal polyps and aspirin intolerance |
| Description | Asthma is a phenotypically heterogeneous disorder with many etiologic factors and clinical characteristics. In some patients with asthma, aspirin and all nonsteroidal anti-inflammatory drugs (NSAIDs) trigger asthmatic attacks. This clinical syndrome is characterized by eosinophilic inflammation of nasal and bronchial tissue, often associated with nasal polyps. It has been reported that genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance. |
| Category | Immune system disease |
| Network | - |
| Gene | TBX21 [HSA:30009] [KO:K10166] PTGER2 [HSA:5732] [KO:K04259] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: CA23.20 ICD-10: J45 MeSH: C565935 OMIM: 208550 |
| Reference | PMID:15806396 AUTHORS Akahoshi M, Obara K, Hirota T, Matsuda A, Hasegawa K, Takahashi N, Shimizu M, Nakashima K, Cheng L, Doi S, Fujiwara H, Miyatake A, Fujita K, Higashi N, Taniguchi M, Enomoto T, Mao XQ, Nakashima H, Adra CN, Nakamura Y, Tamari M, Shirakawa T TITLE Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. JOURNAL Hum Genet 117:16-26 (2005) DOI:10.1007/s00439-005-1285-0 PMID:21370724 AUTHORS Schaper C, Noga O, Koch B, Ewert R, Felix SB, Glaser S, Kunkel G, Gustavus B TITLE Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis. JOURNAL J Investig Allergol Clin Immunol 21:51-8 (2011) PMID:15496426 AUTHORS Jinnai N, Sakagami T, Sekigawa T, Kakihara M, Nakajima T, Yoshida K, Goto S, Hasegawa T, Koshino T, Hasegawa Y, Inoue H, Suzuki N, Sano Y, Inoue I TITLE Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach. JOURNAL Hum Mol Genet 13:3203-17 (2004) DOI:10.1093/hmg/ddh332 |