| H01328 | |
| H number | H01328 |
| Name | Aspergillosis |
| Description | Pulmonary aspergillus infections can be classified based on clinical syndromes into saprophytic infections, allergic disease and invasive disease. Invasive pulmonary aspergillosis, occurring in immunocompromised patients, reflects the most serious disease with a high case-fatality rate. Of the 185 recognized species of Aspergillus, 20 are known to cause infections in humans. Aspergillus fumigatus accounts for about 65 percent of all invasive infections in humans and is the mostly encountered species in pulmonary infections. Aspergillus flavus, Aspergillus niger, Aspergillus terreus and Aspergillus nidulans are less frequently causes of invasive and pulmonary infections. |
| Category | Fungal infectious disease |
| Network | - |
| Gene | CLEC1A (susceptibility) [HSA:51267] [KO:K10069] CLEC7A (susceptibility) [HSA:64581] [KO:K10074] |
| Pathogen | Aspergillus fumigatus [GN:afm] Aspergillus flavus [GN:afv] Aspergillus clavatus [GN:act] |
| Env factor | - |
| Carcinogen | - |
| Drug | Amphotericin B [DR:D00203] Prednisolone sodium phosphate [DR:D00981] Prednisone [DR:D00473] Itraconazole [DR:D00350] Voriconazole [DR:D00578] Posaconazole [DR:D02555] Caspofungin acetate [DR:D02501] Isavuconazonium sulfate [DR:D10643] |
| Comment | - |
| Other DBs | ICD-11: 1F20 ICD-10: B44 MeSH: D001228 MedlinePlus: 001326 OMIM: 614079 |
| Reference | PMID:25135079 AUTHORS Warris A TITLE The biology of pulmonary aspergillus infections. JOURNAL J Infect 69 Suppl 1:S36-41 (2014) DOI:10.1016/j.jinf.2014.07.011 PMID:29489751 (CLEC1A) AUTHORS Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, Plato A, Wallace CA, Yuecel R, Hebecker B, da Gloria Teixeira Sousa M, Cunha C, Liu Y, Feizi T, Brakhage AA, Kwon-Chung KJ, Gow NAR, Zanda M, Piras M, Zanato C, Jaeger M, Netea MG, van de Veerdonk FL, Lacerda JF, Campos A, Carvalho A, Willment JA, Latge JP, Brown GD TITLE Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. JOURNAL Nature 555:382-386 (2018) DOI:10.1038/nature25974 PMID:22674328 (CLEC7A) AUTHORS Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI, Wang HL, McGovern DP, Brown GD, Underhill DM TITLE Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. JOURNAL Science 336:1314-7 (2012) DOI:10.1126/science.1221789 |