H01358 | |
H number | H01358 |
Name | Atopic dermatitis |
Description | Atopic dermatitis (AD) is a relapsing chronic inflammatory skin disease characterized by eczematous skin lesions and intense pruritus. A genetic defect in the filaggrin (FLG) protein and/or environmental factors are thought to cause AD by disrupting the epidermis. This disruption, in turn, results in contact between immune cells in the dermis and antigens from the external environment leading to intense itching, scratching, and inflammation. Apart from FLG, recent genome-wide association studies (GWASs) have identified many susceptibility loci of atopic dermatitis with genome-wide significance. |
Category | Immune system disease; Skin disease |
Network | - |
Gene | FLG (mutation) [HSA:2312] [KO:K10384] IL4 (polymorphism) [HSA:3656] [KO:K04731] IL4RA (polymorphism) [HSA:3566] [KO:K05071] SPINK5 (polymorphism) [HSA:11005] [KO:K23420] IL13 (polymorphism) [HSA:3596] [KO:K05435] RANTES (polymorphism) [HSA:6352] [KO:K12499] NOD1 (polymorphism) [HSA:10392] [KO:K08727] CARD15 (polymorphism) [HSA:64127] [KO:K10165] TLR-2 (polymorphism) [HSA:7097] [KO:K10159] TLR-9 (polymorphism) [HSA:54106] [KO:K10161] COL29A1 (polymorphism) [HSA:256076] [KO:K06238] |
Pathogen | Staphylococcus aureus Malassezia sympodialis [GN:msym] |
Env factor | - |
Carcinogen | - |
Drug | Triamcinolone acetonide [DR:D00983] Dexamethasone [DR:D00292] Dexamethasone sodium phosphate [DR:D00975] Hydrocortisone [DR:D00088] Hydrocortisone sodium succinate [DR:D00978] Hydrocortisone butyrate [DR:D01619] Prednisolone [DR:D00472] Prednisolone sodium phosphate [DR:D00981] Prednisone [DR:D00473] Doxepin hydrochloride [DR:D00814] Methylprednisolone [DR:D00407] Methylprednisolone sodium succinate [DR:D00751] Methylprednisolone acetate [DR:D00979] Desonide [DR:D03696] Tacrolimus [DR:D00107] Pimecrolimus [DR:D05480] Dupilumab [DR:D10354] Crisaborole [DR:D10873] Tralokinumab [DR:D09979] Abrocitinib [DR:D11400] Ruxolitinib phosphate [DR:D09960] Cortisone acetate [DR:D00973] Upadacitinib hydrate [DR:D11048] Hydroxyzine hydrochloride [DR:D00672] Hydroxyzine pamoate [DR:D01096] |
Comment | - |
Other DBs | ICD-11: EA80 ICD-10: L20 MeSH: D003876 OMIM: 605803 |
Reference | PMID:23473856 AUTHORS Kabashima K TITLE New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity. JOURNAL J Dermatol Sci 70:3-11 (2013) DOI:10.1016/j.jdermsci.2013.02.001 PMID:23439055 AUTHORS Tamari M, Tanaka S, Hirota T TITLE Genome-wide association studies of allergic diseases. JOURNAL Allergol Int 62:21-8 (2013) DOI:10.2332/allergolint.13-RAI-0539 PMID:21518425 AUTHORS Bussmann C, Weidinger S, Novak N TITLE Genetics of atopic dermatitis. JOURNAL J Dtsch Dermatol Ges 9:670-6 (2011) DOI:10.1111/j.1610-0387.2011.07656.x PMID:20109730 AUTHORS Barnes KC TITLE An update on the genetics of atopic dermatitis: scratching the surface in 2009. JOURNAL J Allergy Clin Immunol 125:16-29.e1-11; quiz 30-1 (2010) DOI:10.1016/j.jaci.2009.11.008 PMID:22962911 AUTHORS Berke R, Singh A, Guralnick M TITLE Atopic dermatitis: an overview. JOURNAL Am Fam Physician 86:35-42 (2012) PMID:16815133 AUTHORS Cork MJ, Robinson DA, Vasilopoulos Y, Ferguson A, Moustafa M, MacGowan A, Duff GW, Ward SJ, Tazi-Ahnini R TITLE New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions. JOURNAL J Allergy Clin Immunol 118:3-21; quiz 22-3 (2006) DOI:10.1016/j.jaci.2006.04.042 PMID:22586797 AUTHORS Cookson H, Smith C TITLE Systemic treatment of adult atopic dermatitis. JOURNAL Clin Med 12:172-6 (2012) DOI:10.1038/ng1767 PMID:20070141 AUTHORS Simpson EL TITLE Atopic dermatitis: a review of topical treatment options. JOURNAL Curr Med Res Opin 26:633-40 (2010) DOI:10.1185/03007990903512156 PMID:24354911 AUTHORS Simon D, Bieber T TITLE Systemic therapy for atopic dermatitis. JOURNAL Allergy 69:46-55 (2014) DOI:10.1111/all.12339 |