| H01359 | |
| H number | H01359 |
| Name | Anaphylaxis |
| Description | Anaphylaxis is a severe, life-threatening, systemic allergic reaction that is almost always unanticipated and may lead to death by airway obstruction or vascular collapse. Anaphylaxis can be triggered by a broad range of triggers. Food is the commonest trigger in children and drugs the commonest in adults. In addition to the environmental influences, studies suggest that a complex of genes affects the anaphylactic response. Anaphylaxis occurs as the result of an allergen response, usually immunoglobulin E-mediated, which leads to mast cell and basophil activation and a combination of dermatologic, respiratory, cardiovascular, gastrointestinal, and neurologic symptoms. |
| Category | Immune system disease |
| Network | - |
| Gene | c-KIT (mutation) [HSA:3815] [KO:K05091] NLRP3 (polymorphism) [HSA:114548] [KO:K12800] IL-10 (polymorphism) [HSA:3586] [KO:K05443] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Epinephrine [DR:D00095] |
| Comment | - |
| Other DBs | ICD-11: 4A84 MeSH: D000707 |
| Reference | PMID:20560905 AUTHORS Ben-Shoshan M, Clarke AE TITLE Anaphylaxis: past, present and future. JOURNAL Allergy 66:1-14 (2011) DOI:10.1111/j.1398-9995.2010.02422.x PMID:22085665 AUTHORS Arnold JJ, Williams PM TITLE Anaphylaxis: recognition and management. JOURNAL Am Fam Physician 84:1111-8 (2011) PMID:20236436 AUTHORS Younker J, Soar J TITLE Recognition and treatment of anaphylaxis. JOURNAL Nurs Crit Care 15:94-8 (2010) DOI:10.1111/j.1478-5153.2010.00366.x PMID:20176258 AUTHORS Simons FE TITLE Anaphylaxis. JOURNAL J Allergy Clin Immunol 125:S161-81 (2010) DOI:10.1016/j.jaci.2009.12.981 PMID:21682750 AUTHORS Boden SR, Wesley Burks A TITLE Anaphylaxis: a history with emphasis on food allergy. JOURNAL Immunol Rev 242:247-57 (2011) DOI:10.1111/j.1600-065X.2011.01028.x |