| H01361 | |
| H number | H01361 |
| Name | Eosinophilic esophagitis |
| Description | Eosinophilic esophagitis (EoE) is a chronic immune and antigen-mediated clinicopathologic disease that is characterized by eosinophil infiltration into the esophageal epithelium and results in esophageal fibrosis and dysfunction. Several factors contribute to the development of EoE, including genetic predisposition, history of allergies, and presence of environmental and food allergens. Recently, an association between a single nuclear polymorphism (SNP) in the gene encoding thymic stromal lymphopoietin (TSLP) or eotaxin-3 (CCL-26) and risk for EoE was found. |
| Category | Immune system disease |
| Network | - |
| Gene | TSLP (polymorphism) [HSA:85480] [KO:K05436] CCL-26 (polymorphism) [HSA:10344] [KO:K21096] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: DA24.1 MeSH: D057765 |
| Reference | PMID:22313241 AUTHORS Straumann A, Aceves SS, Blanchard C, Collins MH, Furuta GT, Hirano I, Schoepfer AM, Simon D, Simon HU TITLE Pediatric and adult eosinophilic esophagitis: similarities and differences. JOURNAL Allergy 67:477-90 (2012) DOI:10.1111/j.1398-9995.2012.02787.x PMID:21228772 AUTHORS Mulder DJ, Justinich CJ TITLE Understanding eosinophilic esophagitis: the cellular and molecular mechanisms of an emerging disease. JOURNAL Mucosal Immunol 4:139-47 (2011) DOI:10.1038/mi.2010.88 PMID:17088129 AUTHORS Blanchard C, Wang N, Rothenberg ME TITLE Eosinophilic esophagitis: pathogenesis, genetics, and therapy. JOURNAL J Allergy Clin Immunol 118:1054-9 (2006) DOI:10.1016/j.jaci.2006.07.038 PMID:24566295 AUTHORS Merves J, Muir A, Modayur Chandramouleeswaran P, Cianferoni A, Wang ML, Spergel JM TITLE Eosinophilic esophagitis. JOURNAL Ann Allergy Asthma Immunol 112:397-403 (2014) DOI:10.1016/j.anai.2014.01.023 PMID:23130328 AUTHORS Ridolo E, Montagni M, Olivieri E, Rogkakou A, De' Angelis GL, Canonica GW TITLE Eosinophilic esophagitis: which role for food and inhalant allergens? JOURNAL Asia Pac Allergy 2:237-41 (2012) DOI:10.5415/apallergy.2012.2.4.237 PMID:21991511 AUTHORS Shahzad G, Mustacchia P, Frieri M TITLE Role of mucosal inflammation in eosinophilic esophagitis: review of the literature. JOURNAL ISRN Gastroenterol 2011:468073 (2011) DOI:10.5402/2011/468073 PMID:23001405 AUTHORS Redd M, Schey R TITLE Eosinophilic esophagitis: current treatment. JOURNAL Dig Dis Sci 58:613-20 (2013) DOI:10.1007/s10620-012-2383-1 PMID:22034864 AUTHORS Abonia JP, Rothenberg ME TITLE Eosinophilic esophagitis: rapidly advancing insights. JOURNAL Annu Rev Med 63:421-34 (2012) DOI:10.1146/annurev-med-041610-134138 |