SKIP000185 | |
SKIP ID | SKIP000185 |
Organism(En) | - |
Organism(Ja) | - |
Cell Type(En) | - |
Cell Type(Ja) | - |
Cell Tissue(En) | - |
Cell Tissue(Ja) | - |
Cell Origin | Diseased |
Cell Name 1(En) | iPS-SMA3.6 |
Cell Name 1(Ja) | iPS-SMA3.6 |
Cell Name 2(En) | GM23240 |
Cell Name 2(Ja) | GM23240 |
Disease Name 1(Ja) | 脊髄性筋委縮症Ⅰ型 |
ICD Code 1 | G120 |
Disease Name 1(En) | Infantile spinal muscular atrophy, type I [Werdnig-Hoffman] |
OMIM1 | 253300 |
Disease Name 2(Ja) | - |
ICD Code 2 | - |
Disease Name 2(En) | - |
OMIM 2 | - |
Disease Name 3(Ja) | - |
ICD Code 3 | - |
Disease Name 3(En) | - |
OMIM 3 | - |
Age | 3 |
Age Range | 0-9 |
Sex | Male |
Race(En) | - |
Race(Ja) | - |
Genetic Diagnosis | Yes |
Not Detected | No |
Description(En) | Coriell ID: GM23240 iPSCs derived from GM03813 Fibroblast. SMN1 exons 7-8 deleted. |
Description(Ja) | Coriell ID: GM23240 SMA1患者線維芽細胞(GM03813) 由来。 SMN1 exons 7-8欠失 |
Cell Morphology | human ES-like |
Grade | -- |
Vector | Lentivirus |
Transgene | Oct4, Sox2, Nanog, Lin28, lentivirus vector |
Adhesiveness | Yes |
Feeder | Yes |
Feeder Cell | CF1 MEFs on 0.1% Gelatin |
Medium | Ham's F12 Medium/Dulbecco Modified Eagles Medium, 1:1 mixture with 2mM L-glutamine |
Genome Editing | - |
CO2 | - |
Mycoplasma | - |
Detection of Contaminants Mycoplasma | - |
Pluripotent Markers | - |
Pluripotent Markers Assay | - |
in vitro Differentiation | - |
in vitro Differentiation Assay | - |
in vivo Differentiation | - |
in vivo Differentiation Assay | - |
Other 1 Assay | - |
Other 1 Assay Method | - |
Other 2 Assay | - |
Other 2 Assay Method | - |
Other 3 Assay | - |
Other 3 Assay Method | - |
Karyotype | Yes |
Karyotype Assay | 45,X[1]/47,XYY[1]/46,XY[48].arr(1-22)x2,(XY)x1 |
Remaining Vector Detection | - |
Remaining Vector Detection Assay | - |
STR | - |
HLA | - |
Stem Cell Transcriptome analysis | - |
Stem Cell Transcriptome analysis Assay | - |
Author Name(En) | Allison D Ebert |
Author Name(Ja) | Allison D Ebert |
Author Organization(En) | University of Wisconsin Madison |
Author Organization(Ja) | University of Wisconsin Madison |
Author Contact Email | - |
PI Organization(En) | - |
PI Organization(Ja) | - |
PI Name(En) | - |
PI Name(Ja) | - |
PI Contact Email | - |
Availability | Available |
Provider Organization(En) | NIGMS Coriell Cell Repository |
Provider Organization(Ja) | NIGMS Coriell Cell Repository |
Provider Email | - |
Provider URL | http://ccr.coriell.org/Sections/Collections/NIGMS/ipsc_list.aspx?PgId=696 |
Ethical Statement(En) | - |
Ethical Statement(Ja) | - |
Terms of Use(En) | - |
Terms of Use(Ja) | - |
PubMed ID | 20558385 -- 19098894 |
DOI | 10.1001/archneurol.2010.89 -- 10.1038/nature07677 |
Title | Stem Cell Model of Spinal Muscular Atrophy -- Induced pluripotent stem cells from a spinal muscular atrophy patient. |
Authors | Ebert, A.D. and Svendsen, C.N. -- Ebert AD, Yu J, Rose FF Jr, Mattis VB, Lorson CL, Thomson JA, Svendsen CN |
Journal | Arch Neurol -- Nature |
Year | 2010 -- 2008 |
Volume | 67 -- 457 |
Issue | 6 -- 7227 |
Pages | 665-669 -- 277-80 |
URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=20558385 -- http://www.ncbi.nlm.nih.gov/pubmed/?term=19098894 |
Free input | -- |
Note | - |