SKIP000909 |
SKIP ID |
SKIP000909 |
Organism(En) |
- |
Organism(Ja) |
- |
Cell Type(En) |
- |
Cell Type(Ja) |
- |
Cell Tissue(En) |
- |
Cell Tissue(Ja) |
- |
Cell Origin |
Diseased |
Cell Name 1(En) |
Alex1 |
Cell Name 1(Ja) |
Alex1 |
Cell Name 2(En) |
- |
Cell Name 2(Ja) |
- |
Disease Name 1(Ja) |
アレキサンダー病 |
ICD Code 1 |
E752 |
Disease Name 1(En) |
Alexander disease |
OMIM1 |
203450 |
Disease Name 2(Ja) |
- |
ICD Code 2 |
- |
Disease Name 2(En) |
- |
OMIM 2 |
- |
Disease Name 3(Ja) |
- |
ICD Code 3 |
- |
Disease Name 3(En) |
- |
OMIM 3 |
- |
Age |
6 |
Age Range |
0-9 |
Sex |
Male |
Race(En) |
Caucasian |
Race(Ja) |
Caucasian |
Genetic Diagnosis |
Yes |
Not Detected |
No |
Description(En) |
iPSCs derived from Alexander's disease patients(GM16825) |
Description(Ja) |
アレキサンダー病患者(GM16825)由来iPS細胞。 |
Cell Morphology |
human ES-like |
Grade |
Research Grade |
Vector |
Other |
Transgene |
SOX2, KLF4, OCT4, L-MYC, LIN28, siRNA for p53 |
Adhesiveness |
- |
Feeder |
Yes |
Feeder Cell |
SNL feeder cells |
Medium |
human ES cell medium (ReproCell, Yokohama, Japan) comprising 4 ng/mL of bFGF (Wako Chemicals, Osaka, Japan) |
Genome Editing |
- |
CO2 |
- |
Mycoplasma |
Unknown |
Detection of Contaminants Mycoplasma |
- |
Pluripotent Markers |
Yes |
Pluripotent Markers Assay |
Immunofluorescent assay |
in vitro Differentiation |
Yes |
in vitro Differentiation Assay |
Immunofluorescent assay |
in vivo Differentiation |
- |
in vivo Differentiation Assay |
- |
Other 1 Assay |
Yes |
Other 1 Assay Method |
- |
Other 2 Assay |
- |
Other 2 Assay Method |
- |
Other 3 Assay |
- |
Other 3 Assay Method |
- |
Karyotype |
Yes |
Karyotype Assay |
Karyotype analysis |
Remaining Vector Detection |
Yes |
Remaining Vector Detection Assay |
PCR |
STR |
- |
HLA |
- |
Stem Cell Transcriptome analysis |
- |
Stem Cell Transcriptome analysis Assay |
- |
Author Name(En) |
Takayuki Kondo |
Author Name(Ja) |
近藤 孝之 |
Author Organization(En) |
Center for iPS Cell Research and Application (CiRA), Kyoto University |
Author Organization(Ja) |
京都大学iPS細胞研究所 |
Author Contact Email |
ips-contact[at]cira[dot]kyoto-u[dot]ac[dot]jp |
PI Organization(En) |
Center for iPS Cell Research and Application (CiRA), Kyoto University |
PI Organization(Ja) |
京都大学CiRA増殖機構分化機構研究部門 |
PI Name(En) |
Haruhisa Inoue |
PI Name(Ja) |
井上 治久 |
PI Contact Email |
- |
Availability |
Information Only |
Provider Organization(En) |
Center for iPS Cell Research and Application (CiRA), Kyoto University |
Provider Organization(Ja) |
京都大学iPS細胞研究所 |
Provider Email |
ips-contact[at]cira[dot]kyoto-u[dot]ac[dot]jp |
Provider URL |
http://www.cira.kyoto-u.ac.jp/ |
Ethical Statement(En) |
- |
Ethical Statement(Ja) |
- |
Terms of Use(En) |
- |
Terms of Use(Ja) |
- |
PubMed ID |
27402089 |
DOI |
10.1186/s40478-016-0337-0 |
Title |
Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes. |
Authors |
Kondo T, Funayama M, Miyake M, Tsukita K, Era T, Osaka H, Ayaki T, Takahashi R, Inoue H |
Journal |
Acta Neuropathol Commun |
Year |
2016 |
Volume |
4 |
Issue |
1 |
Pages |
69 |
URL |
http://www.ncbi.nlm.nih.gov/pubmed/27402089 |
Free input |
- |
Note |
- |