SKIP000734 |
SKIP ID |
SKIP000734 |
Organism(En) |
- |
Organism(Ja) |
- |
Cell Type(En) |
- |
Cell Type(Ja) |
- |
Cell Tissue(En) |
- |
Cell Tissue(Ja) |
- |
Cell Origin |
Diseased |
Cell Name 1(En) |
GM24675 |
Cell Name 1(Ja) |
GM24675 |
Cell Name 2(En) |
APPDp2 |
Cell Name 2(Ja) |
APPDp2 |
Disease Name 1(Ja) |
アルツハイマー病 |
ICD Code 1 |
G309 |
Disease Name 1(En) |
ALZHEIMER DISEASE |
OMIM1 |
104300 |
Disease Name 2(Ja) |
- |
ICD Code 2 |
- |
Disease Name 2(En) |
- |
OMIM 2 |
- |
Disease Name 3(Ja) |
- |
ICD Code 3 |
- |
Disease Name 3(En) |
- |
OMIM 3 |
- |
Age |
60 |
Age Range |
60-69 |
Sex |
Female |
Race(En) |
FINNISH |
Race(Ja) |
FINNISH |
Genetic Diagnosis |
Yes |
Not Detected |
Yes |
Description(En) |
ALZHEIMER DISEASE(Familial AD, APP duplication) hiPSC derived from fibroblast |
Description(Ja) |
家族性アルツハイマー病患者(APP遺伝子重複)維芽細胞由来iPS細胞 |
Cell Morphology |
human ES-like |
Grade |
Research Grade |
Vector |
Retrovirus |
Transgene |
OCT4, SOX2, KLF4, CMYC |
Adhesiveness |
Yes |
Feeder |
Yes |
Feeder Cell |
CF1 MEFs |
Medium |
Knockout DMEM + 20% Knock-out Serum Replacement |
Genome Editing |
- |
CO2 |
5% |
Mycoplasma |
Negative |
Detection of Contaminants Mycoplasma |
- |
Pluripotent Markers |
Yes |
Pluripotent Markers Assay |
Surface antigen expression and alkaline phosphatase |
in vitro Differentiation |
Yes |
in vitro Differentiation Assay |
EB formation assay and Pluritest |
in vivo Differentiation |
Yes |
in vivo Differentiation Assay |
Teratoma formation |
Other 1 Assay |
- |
Other 1 Assay Method |
- |
Other 2 Assay |
- |
Other 2 Assay Method |
- |
Other 3 Assay |
- |
Other 3 Assay Method |
- |
Karyotype |
Yes |
Karyotype Assay |
- |
Remaining Vector Detection |
- |
Remaining Vector Detection Assay |
- |
STR |
Yes |
HLA |
- |
Stem Cell Transcriptome analysis |
Yes |
Stem Cell Transcriptome analysis Assay |
Real-time PCR |
Author Name(En) |
Mason A. Israel |
Author Name(Ja) |
Mason A. Israel |
Author Organization(En) |
University of California San Diego |
Author Organization(Ja) |
University of California San Diego |
Author Contact Email |
- |
PI Organization(En) |
University of California San Diego |
PI Organization(Ja) |
University of California San Diego |
PI Name(En) |
Lawrence S. B. Goldstein |
PI Name(Ja) |
Lawrence S. B. Goldstein |
PI Contact Email |
- |
Availability |
Available |
Provider Organization(En) |
Coriell Institute |
Provider Organization(Ja) |
Coriell Institute |
Provider Email |
- |
Provider URL |
https://catalog.coriell.org |
Ethical Statement(En) |
- |
Ethical Statement(Ja) |
- |
Terms of Use(En) |
- |
Terms of Use(Ja) |
- |
PubMed ID |
22278060 |
DOI |
10.1038/nature10821 |
Title |
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. |
Authors |
Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS |
Journal |
Nature |
Year |
2012 |
Volume |
482 |
Issue |
7384 |
Pages |
216-20 |
URL |
http://www.ncbi.nlm.nih.gov/pubmed/22278060 |
Free input |
- |
Note |
- |