SKIP000734
SKIP ID SKIP000734
Organism(En) -
Organism(Ja) -
Cell Type(En) -
Cell Type(Ja) -
Cell Tissue(En) -
Cell Tissue(Ja) -
Cell Origin Diseased
Cell Name 1(En) GM24675
Cell Name 1(Ja) GM24675
Cell Name 2(En) APPDp2
Cell Name 2(Ja) APPDp2
Disease Name 1(Ja) アルツハイマー病
ICD Code 1 G309
Disease Name 1(En) ALZHEIMER DISEASE
OMIM1 104300
Disease Name 2(Ja) -
ICD Code 2 -
Disease Name 2(En) -
OMIM 2 -
Disease Name 3(Ja) -
ICD Code 3 -
Disease Name 3(En) -
OMIM 3 -
Age 60
Age Range 60-69
Sex Female
Race(En) FINNISH
Race(Ja) FINNISH
Genetic Diagnosis Yes
Not Detected Yes
Description(En) ALZHEIMER DISEASE(Familial AD, APP duplication) hiPSC derived from fibroblast
Description(Ja) 家族性アルツハイマー病患者(APP遺伝子重複)維芽細胞由来iPS細胞
Cell Morphology human ES-like
Grade Research Grade
Vector Retrovirus
Transgene OCT4, SOX2, KLF4, CMYC
Adhesiveness Yes
Feeder Yes
Feeder Cell CF1 MEFs
Medium Knockout DMEM + 20% Knock-out Serum Replacement
Genome Editing -
CO2 5%
Mycoplasma Negative
Detection of Contaminants Mycoplasma -
Pluripotent Markers Yes
Pluripotent Markers Assay Surface antigen expression and alkaline phosphatase
in vitro Differentiation Yes
in vitro Differentiation Assay EB formation assay and Pluritest
in vivo Differentiation Yes
in vivo Differentiation Assay Teratoma formation
Other 1 Assay -
Other 1 Assay Method -
Other 2 Assay -
Other 2 Assay Method -
Other 3 Assay -
Other 3 Assay Method -
Karyotype Yes
Karyotype Assay -
Remaining Vector Detection -
Remaining Vector Detection Assay -
STR Yes
HLA -
Stem Cell Transcriptome analysis Yes
Stem Cell Transcriptome analysis Assay Real-time PCR
Author Name(En) Mason A. Israel
Author Name(Ja) Mason A. Israel
Author Organization(En) University of California San Diego
Author Organization(Ja) University of California San Diego
Author Contact Email -
PI Organization(En) University of California San Diego
PI Organization(Ja) University of California San Diego
PI Name(En) Lawrence S. B. Goldstein
PI Name(Ja) Lawrence S. B. Goldstein
PI Contact Email -
Availability Available
Provider Organization(En) Coriell Institute
Provider Organization(Ja) Coriell Institute
Provider Email -
Provider URL https://catalog.coriell.org
Ethical Statement(En) -
Ethical Statement(Ja) -
Terms of Use(En) -
Terms of Use(Ja) -
PubMed ID 22278060
DOI 10.1038/nature10821
Title Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.
Authors Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS
Journal Nature
Year 2012
Volume 482
Issue 7384
Pages 216-20
URL http://www.ncbi.nlm.nih.gov/pubmed/22278060
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