| SKIP000794 | |
| SKIP ID | SKIP000794 |
| Organism(En) | - |
| Organism(Ja) | - |
| Cell Type(En) | - |
| Cell Type(Ja) | - |
| Cell Tissue(En) | - |
| Cell Tissue(Ja) | - |
| Cell Origin | Diseased |
| Cell Name 1(En) | LQTS-hiPSCs |
| Cell Name 1(Ja) | LQTS-hiPSCs |
| Cell Name 2(En) | - |
| Cell Name 2(Ja) | - |
| Disease Name 1(Ja) | 遺伝性ＱＴ延長症候群2型 |
| ICD Code 1 | I45.8 |
| Disease Name 1(En) | long-QT syndrome type 2 |
| OMIM1 | 613688 |
| Disease Name 2(Ja) | - |
| ICD Code 2 | - |
| Disease Name 2(En) | - |
| OMIM 2 | - |
| Disease Name 3(Ja) | - |
| ICD Code 3 | - |
| Disease Name 3(En) | - |
| OMIM 3 | - |
| Age | 28 |
| Age Range | 20-29 |
| Sex | Female |
| Race(En) | - |
| Race(Ja) | - |
| Genetic Diagnosis | Yes |
| Not Detected | No |
| Description(En) | Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome type2 |
| Description(Ja) | QT 延長症候群 2 型患者由来iPS細胞 |
| Cell Morphology | -- |
| Grade | -- |
| Vector | Retrovirus |
| Transgene | SOX-2, KLF-4, OCT-4 |
| Adhesiveness | - |
| Feeder | Yes |
| Feeder Cell | MEF |
| Medium | ES medium and treated with 0.9 mM valproic acid |
| Genome Editing | - |
| CO2 | - |
| Mycoplasma | - |
| Detection of Contaminants Mycoplasma | - |
| Pluripotent Markers | Yes |
| Pluripotent Markers Assay | Immunofluoresence, ALP staining, RT-PCR |
| in vitro Differentiation | Yes |
| in vitro Differentiation Assay | Embryoid body formation and Cardiomyocyte differentiation |
| in vivo Differentiation | Yes |
| in vivo Differentiation Assay | Teratoma formation |
| Other 1 Assay | Yes |
| Other 1 Assay Method | Bisulphite sequencing |
| Other 2 Assay | No |
| Other 2 Assay Method | - |
| Other 3 Assay | - |
| Other 3 Assay Method | - |
| Karyotype | Yes |
| Karyotype Assay | Standard G-banding chromosome analysis |
| Remaining Vector Detection | Yes |
| Remaining Vector Detection Assay | qRT-PCR |
| STR | - |
| HLA | - |
| Stem Cell Transcriptome analysis | - |
| Stem Cell Transcriptome analysis Assay | - |
| Author Name(En) | IIanit Itzhaki |
| Author Name(Ja) | IIanit Itzhaki |
| Author Organization(En) | Sohnis Family Reserch Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Bruce Rappaport Faculty of Medicine, Technion -Israel Institute of Technology |
| Author Organization(Ja) | Sohnis Family Reserch Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Bruce Rappaport Faculty of Medicine, Technion -Israel Institute of Technology |
| Author Contact Email | - |
| PI Organization(En) | - |
| PI Organization(Ja) | - |
| PI Name(En) | - |
| PI Name(Ja) | - |
| PI Contact Email | - |
| Availability | Information Only |
| Provider Organization(En) | - |
| Provider Organization(Ja) | - |
| Provider Email | - |
| Provider URL | - |
| Ethical Statement(En) | - |
| Ethical Statement(Ja) | - |
| Terms of Use(En) | - |
| Terms of Use(Ja) | - |
| PubMed ID | 21240260 |
| DOI | 10.1038/nature09747 |
| Title | Modelling the long QT syndrome with induced pluripotent stem cells. |
| Authors | Itzhaki I, Maizels L, Huber I, Zwi-Dantsis L, Caspi O, Winterstern A, Feldman O, Gepstein A, Arbel G, Hammerman H, Boulos M, Gepstein L |
| Journal | Nature |
| Year | 2011 |
| Volume | 471 |
| Issue | 7337 |
| Pages | 225-9 |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/21240260 |
| Free input | - |
| Note | - |