| SKIP000322 |
| SKIP ID |
SKIP000322 |
| Organism(En) |
- |
| Organism(Ja) |
- |
| Cell Type(En) |
- |
| Cell Type(Ja) |
- |
| Cell Tissue(En) |
- |
| Cell Tissue(Ja) |
- |
| Cell Origin |
Diseased |
| Cell Name 1(En) |
30iALS-n1 |
| Cell Name 1(Ja) |
30iALS-n1 |
| Cell Name 2(En) |
- |
| Cell Name 2(Ja) |
- |
| Disease Name 1(Ja) |
筋萎縮性側索硬化症 |
| ICD Code 1 |
G122 |
| Disease Name 1(En) |
Amyotrophic Lateral Sclerosis |
| OMIM1 |
105550 |
| Disease Name 2(Ja) |
前頭側頭型認知症 |
| ICD Code 2 |
G131 |
| Disease Name 2(En) |
Front Temporal Dementia |
| OMIM 2 |
105550 |
| Disease Name 3(Ja) |
- |
| ICD Code 3 |
- |
| Disease Name 3(En) |
- |
| OMIM 3 |
- |
| Age |
- |
| Age Range |
50-59 |
| Sex |
Female |
| Race(En) |
- |
| Race(Ja) |
- |
| Genetic Diagnosis |
Yes |
| Not Detected |
No |
| Description(En) |
iPSC with GGGGCC-repeat expansion in C9ORF72. RNA foci containing GGGGCC-repeat C9ORF72 are detected in C9-ALS patient-derived motor neurons
|
| Description(Ja) |
iPSC with GGGGCC-repeat expansion in C9ORF72. RNA foci containing GGGGCC-repeat C9ORF72 are detected in C9-ALS patient-derived motor neurons
|
| Cell Morphology |
-- |
| Grade |
Research Grade |
| Vector |
Plasmid |
| Transgene |
Oct4, Sox2, Klf4, L-Myc, Lin28, p53 shRNA |
| Adhesiveness |
- |
| Feeder |
No |
| Feeder Cell |
- |
| Medium |
mTeSR1 medium |
| Genome Editing |
- |
| CO2 |
- |
| Mycoplasma |
- |
| Detection of Contaminants Mycoplasma |
- |
| Pluripotent Markers |
Yes |
| Pluripotent Markers Assay |
Immunostaining and Flow cytometry |
| in vitro Differentiation |
Yes |
| in vitro Differentiation Assay |
Immunostaining, RT-PCR |
| in vivo Differentiation |
No |
| in vivo Differentiation Assay |
- |
| Other 1 Assay |
Yes |
| Other 1 Assay Method |
PluriTest characterization |
| Other 2 Assay |
Yes |
| Other 2 Assay Method |
southern blot |
| Other 3 Assay |
Yes |
| Other 3 Assay Method |
Cedars Sinai's stem cell core standard characterization |
| Karyotype |
Yes |
| Karyotype Assay |
G-band |
| Remaining Vector Detection |
Yes |
| Remaining Vector Detection Assay |
qRT-PCR |
| STR |
No |
| HLA |
No |
| Stem Cell Transcriptome analysis |
No |
| Stem Cell Transcriptome analysis Assay |
- |
| Author Name(En) |
Robert H. Baloh |
| Author Name(Ja) |
Robert H. Baloh |
| Author Organization(En) |
Regenerative Medicine Institute, Cedars-Sinai Medical Center |
| Author Organization(Ja) |
Regenerative Medicine Institute, Cedars-Sinai Medical Center |
| Author Contact Email |
- |
| PI Organization(En) |
- |
| PI Organization(Ja) |
- |
| PI Name(En) |
- |
| PI Name(Ja) |
- |
| PI Contact Email |
- |
| Availability |
Information Only |
| Provider Organization(En) |
Regenerative Medicine Institute, Cedars-Sinai Medical Center |
| Provider Organization(Ja) |
Regenerative Medicine Institute, Cedars-Sinai Medical Center |
| Provider Email |
- |
| Provider URL |
- |
| Ethical Statement(En) |
- |
| Ethical Statement(Ja) |
- |
| Terms of Use(En) |
- |
| Terms of Use(Ja) |
- |
| PubMed ID |
24154603 |
| DOI |
10.1126/scitranslmed.3007529 |
| Title |
Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. |
| Authors |
Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, Rigo F, Bennett CF, Otis TS, Svendsen CN, Baloh RH |
| Journal |
Sci Transl Med |
| Year |
2013 |
| Volume |
5 |
| Issue |
208 |
| Pages |
208ra149 |
| URL |
http://www.ncbi.nlm.nih.gov/pubmed/24154603 |
| Free input |
- |
| Note |
- |