| SKIP000326 | |
| SKIP ID | SKIP000326 |
| Organism(En) | - |
| Organism(Ja) | - |
| Cell Type(En) | - |
| Cell Type(Ja) | - |
| Cell Tissue(En) | - |
| Cell Tissue(Ja) | - |
| Cell Origin | Diseased |
| Cell Name 1(En) | Carrier2 #1 |
| Cell Name 1(Ja) | Carrier2 #1 |
| Cell Name 2(En) | - |
| Cell Name 2(Ja) | - |
| Disease Name 1(Ja) | 前頭側頭型認知症 |
| ICD Code 1 | G310 |
| Disease Name 1(En) | FrontoTemporal Dementia |
| OMIM1 | 10550 |
| Disease Name 2(Ja) | 筋萎縮性側索硬化症 |
| ICD Code 2 | G122 |
| Disease Name 2(En) | Amytrophic Lateral Sclerosis |
| OMIM 2 | 10550 |
| Disease Name 3(Ja) | - |
| ICD Code 3 | - |
| Disease Name 3(En) | - |
| OMIM 3 | - |
| Age | - |
| Age Range | -- |
| Sex | -- |
| Race(En) | - |
| Race(Ja) | - |
| Genetic Diagnosis | Yes |
| Not Detected | No |
| Description(En) | C9ORF72 GGGGCC repeat expansion is greatly reduced compared during reprograming or clonal expansion |
| Description(Ja) | C9ORF72 GGGGCC repeat expansion is greatly reduced during reprograming or clonal expansion |
| Cell Morphology | -- |
| Grade | Research Grade |
| Vector | Retrovirus |
| Transgene | OCT3/4, SOX2, KLF4, c-MYC |
| Adhesiveness | - |
| Feeder | No |
| Feeder Cell | - |
| Medium | mTeSR1 medium |
| Genome Editing | - |
| CO2 | - |
| Mycoplasma | - |
| Detection of Contaminants Mycoplasma | - |
| Pluripotent Markers | Yes |
| Pluripotent Markers Assay | Immunocytochemistry |
| in vitro Differentiation | Yes |
| in vitro Differentiation Assay | Immunocytochemistry |
| in vivo Differentiation | No |
| in vivo Differentiation Assay | - |
| Other 1 Assay | Yes |
| Other 1 Assay Method | Southern blot |
| Other 2 Assay | - |
| Other 2 Assay Method | - |
| Other 3 Assay | - |
| Other 3 Assay Method | - |
| Karyotype | Yes |
| Karyotype Assay | G-banding |
| Remaining Vector Detection | Yes |
| Remaining Vector Detection Assay | quantitative RT-PCR |
| STR | No |
| HLA | No |
| Stem Cell Transcriptome analysis | No |
| Stem Cell Transcriptome analysis Assay | - |
| Author Name(En) | Fen-Biao Gao |
| Author Name(Ja) | Fen-Biao Gao |
| Author Organization(En) | Department of Neurology, University of Massachusetts Medical School |
| Author Organization(Ja) | Department of Neurology, University of Massachusetts Medical School |
| Author Contact Email | - |
| PI Organization(En) | - |
| PI Organization(Ja) | - |
| PI Name(En) | - |
| PI Name(Ja) | - |
| PI Contact Email | - |
| Availability | Information Only |
| Provider Organization(En) | Department of Neurology, University of Massachusetts Medical School |
| Provider Organization(Ja) | Department of Neurology, University of Massachusetts Medical School |
| Provider Email | - |
| Provider URL | - |
| Ethical Statement(En) | - |
| Ethical Statement(Ja) | - |
| Terms of Use(En) | - |
| Terms of Use(Ja) | - |
| PubMed ID | 23836290 |
| DOI | 10.1007/s00401-013-1149-y |
| Title | Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons. |
| Authors | Almeida S, Gascon E, Tran H, Chou HJ, Gendron TF, Degroot S, Tapper AR, Sellier C, Charlet-Berguerand N, Karydas A, Seeley WW, Boxer AL, Petrucelli L, Miller BL, Gao FB |
| Journal | Acta Neuropathol |
| Year | 2013 |
| Volume | 126 |
| Issue | 3 |
| Pages | 385-99 |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/23836290 |
| Free input | - |
| Note | - |