SKIP000327 |
SKIP ID |
SKIP000327 |
Organism(En) |
- |
Organism(Ja) |
- |
Cell Type(En) |
- |
Cell Type(Ja) |
- |
Cell Tissue(En) |
- |
Cell Tissue(Ja) |
- |
Cell Origin |
Diseased |
Cell Name 1(En) |
Carrier2 #11 |
Cell Name 1(Ja) |
Carrier2 #11 |
Cell Name 2(En) |
- |
Cell Name 2(Ja) |
- |
Disease Name 1(Ja) |
前頭側頭型認知症 |
ICD Code 1 |
G310 |
Disease Name 1(En) |
FrontoTemporal Dementia |
OMIM1 |
10550 |
Disease Name 2(Ja) |
筋萎縮性側索硬化症 |
ICD Code 2 |
G122 |
Disease Name 2(En) |
Amytrophic Lateral Sclerosis |
OMIM 2 |
10550 |
Disease Name 3(Ja) |
- |
ICD Code 3 |
- |
Disease Name 3(En) |
- |
OMIM 3 |
- |
Age |
- |
Age Range |
-- |
Sex |
-- |
Race(En) |
- |
Race(Ja) |
- |
Genetic Diagnosis |
Yes |
Not Detected |
No |
Description(En) |
>1000 GGGGCC repeats in C9ORF72 |
Description(Ja) |
>1000 GGGGCC repeats in C9ORF72 |
Cell Morphology |
-- |
Grade |
Research Grade |
Vector |
Retrovirus |
Transgene |
OCT3/4, SOX2, KLF4, c-MYC |
Adhesiveness |
- |
Feeder |
No |
Feeder Cell |
- |
Medium |
mTeSR1 medium |
Genome Editing |
- |
CO2 |
- |
Mycoplasma |
- |
Detection of Contaminants Mycoplasma |
- |
Pluripotent Markers |
Yes |
Pluripotent Markers Assay |
Immunocytochemistry |
in vitro Differentiation |
Yes |
in vitro Differentiation Assay |
Immunocytochemistry |
in vivo Differentiation |
No |
in vivo Differentiation Assay |
- |
Other 1 Assay |
Yes |
Other 1 Assay Method |
Southern blot |
Other 2 Assay |
Yes |
Other 2 Assay Method |
Immunocytochemistr |
Other 3 Assay |
Yes |
Other 3 Assay Method |
Electrophysiology |
Karyotype |
Yes |
Karyotype Assay |
G-banding |
Remaining Vector Detection |
Yes |
Remaining Vector Detection Assay |
quantitative RT-PCR |
STR |
No |
HLA |
No |
Stem Cell Transcriptome analysis |
No |
Stem Cell Transcriptome analysis Assay |
- |
Author Name(En) |
Fen-Biao Gao |
Author Name(Ja) |
Fen-Biao Gao |
Author Organization(En) |
Department of Neurology, University of Massachusetts Medical School |
Author Organization(Ja) |
Department of Neurology, University of Massachusetts Medical School |
Author Contact Email |
- |
PI Organization(En) |
- |
PI Organization(Ja) |
- |
PI Name(En) |
- |
PI Name(Ja) |
- |
PI Contact Email |
- |
Availability |
Information Only |
Provider Organization(En) |
Department of Neurology, University of Massachusetts Medical School |
Provider Organization(Ja) |
Department of Neurology, University of Massachusetts Medical School |
Provider Email |
- |
Provider URL |
- |
Ethical Statement(En) |
- |
Ethical Statement(Ja) |
- |
Terms of Use(En) |
- |
Terms of Use(Ja) |
- |
PubMed ID |
23836290 |
DOI |
10.1007/s00401-013-1149-y |
Title |
Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons. |
Authors |
Almeida S, Gascon E, Tran H, Chou HJ, Gendron TF, Degroot S, Tapper AR, Sellier C, Charlet-Berguerand N, Karydas A, Seeley WW, Boxer AL, Petrucelli L, Miller BL, Gao FB |
Journal |
Acta Neuropathol |
Year |
2013 |
Volume |
126 |
Issue |
3 |
Pages |
385-99 |
URL |
http://www.ncbi.nlm.nih.gov/pubmed/23836290 |
Free input |
- |
Note |
- |