| SKIP000318 | |
| SKIP ID | SKIP000318 |
| Organism(En) | - |
| Organism(Ja) | - |
| Cell Type(En) | - |
| Cell Type(Ja) | - |
| Cell Tissue(En) | - |
| Cell Tissue(Ja) | - |
| Cell Origin | Diseased |
| Cell Name 1(En) | 77iSMA |
| Cell Name 1(Ja) | 77iSMA |
| Cell Name 2(En) | - |
| Cell Name 2(Ja) | - |
| Disease Name 1(Ja) | 脊髄性筋萎縮症Ⅰ型 |
| ICD Code 1 | G120 |
| Disease Name 1(En) | Spinal muscular atrophy 1 (SMA1) |
| OMIM1 | 253300 |
| Disease Name 2(Ja) | - |
| ICD Code 2 | - |
| Disease Name 2(En) | - |
| OMIM 2 | - |
| Disease Name 3(Ja) | - |
| ICD Code 3 | - |
| Disease Name 3(En) | - |
| OMIM 3 | - |
| Age | - |
| Age Range | 0-9 |
| Sex | Male |
| Race(En) | - |
| Race(Ja) | - |
| Genetic Diagnosis | Yes |
| Not Detected | No |
| Description(En) | derived from Coriell ID GM09677 fibroblasts. Homozygous SMN1 7-8 exons deletion. |
| Description(Ja) | derived from Coriell ID GM09677 fibroblasts. Homozygous SMN1 7-8 exons deletion. |
| Cell Morphology | -- |
| Grade | Research Grade |
| Vector | Plasmid |
| Transgene | Oct4 Klf4 Nanog Lin28 Sox2 c-Myc in OriP-EBNA vector (JA Thomson) |
| Adhesiveness | - |
| Feeder | Yes |
| Feeder Cell | MEF |
| Medium | - |
| Genome Editing | - |
| CO2 | - |
| Mycoplasma | - |
| Detection of Contaminants Mycoplasma | - |
| Pluripotent Markers | Yes |
| Pluripotent Markers Assay | immunocytochemistory,qRT-PCR |
| in vitro Differentiation | - |
| in vitro Differentiation Assay | - |
| in vivo Differentiation | Yes |
| in vivo Differentiation Assay | teratoma formation assay |
| Other 1 Assay | - |
| Other 1 Assay Method | - |
| Other 2 Assay | - |
| Other 2 Assay Method | - |
| Other 3 Assay | - |
| Other 3 Assay Method | - |
| Karyotype | No |
| Karyotype Assay | - |
| Remaining Vector Detection | No |
| Remaining Vector Detection Assay | - |
| STR | No |
| HLA | No |
| Stem Cell Transcriptome analysis | No |
| Stem Cell Transcriptome analysis Assay | - |
| Author Name(En) | Dhruv Sareen -- Allison D. Ebert |
| Author Name(Ja) | Dhruv Sareen -- Allison D. Ebert |
| Author Organization(En) | Regenerative Medicine Institute, Cedars-Sinai Medical Center -- Medical College of Wisconsin |
| Author Organization(Ja) | Regenerative Medicine Institute, Cedars-Sinai Medical Center -- Medical College of Wisconsin |
| Author Contact Email | -- |
| PI Organization(En) | - |
| PI Organization(Ja) | - |
| PI Name(En) | - |
| PI Name(Ja) | - |
| PI Contact Email | - |
| Availability | Information Only |
| Provider Organization(En) | Regenerative Medicine Institute, Cedars-Sinai Medical Center |
| Provider Organization(Ja) | Regenerative Medicine Institute, Cedars-Sinai Medical Center |
| Provider Email | - |
| Provider URL | - |
| Ethical Statement(En) | - |
| Ethical Statement(Ja) | - |
| Terms of Use(En) | - |
| Terms of Use(Ja) | - |
| PubMed ID | 22723941 |
| DOI | 10.1371/journal.pone.0039113 |
| Title | Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. |
| Authors | Sareen D, Ebert AD, Heins BM, McGivern JV, Ornelas L, Svendsen CN |
| Journal | PLoS One |
| Year | 2012 |
| Volume | 7 |
| Issue | 6 |
| Pages | e39113 |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/22723941 |
| Free input | - |
| Note | - |