SKIP000922
SKIP ID SKIP000922
Organism(En) -
Organism(Ja) -
Cell Type(En) -
Cell Type(Ja) -
Cell Tissue(En) dermal fibroblast
Cell Tissue(Ja) 表皮繊維芽細胞
Cell Origin Diseased
Cell Name 1(En) CPVT-iPS c1
Cell Name 1(Ja) CPVT-iPS c1
Cell Name 2(En) -
Cell Name 2(Ja) -
Disease Name 1(Ja) カテコラミン誘発多形性心室頻拍1型
ICD Code 1 I47.2
Disease Name 1(En) Catecholaminergic polymorphic ventricular tachycardia type 1
OMIM1 604772
Disease Name 2(Ja) -
ICD Code 2 -
Disease Name 2(En) -
OMIM 2 -
Disease Name 3(Ja) -
ICD Code 3 -
Disease Name 3(En) -
OMIM 3 -
Age 46
Age Range 40-49
Sex Female
Race(En) -
Race(Ja) -
Genetic Diagnosis Yes
Not Detected No
Description(En) iPS cell line
Description(Ja) iPS細胞
Cell Morphology human ES-like
Grade Research Grade
Vector Retrovirus
Transgene SOX2, KLF4, OCT3/4 and c-MYC (pMX-based plasmids)
Adhesiveness Yes
Feeder Yes
Feeder Cell irradiated MEFs
Medium DMEM/F12 medium supplemented withGlutamax, 20% knockout serum replacer, 1% NAA, 0.1 mmol/L 2ME and 50 ng/ml bFGF
Genome Editing -
CO2 -
Mycoplasma -
Detection of Contaminants Mycoplasma -
Pluripotent Markers Yes
Pluripotent Markers Assay immunocytochemistry
in vitro Differentiation Yes
in vitro Differentiation Assay differentiation to cardiomyocytes
in vivo Differentiation Yes
in vivo Differentiation Assay teratoma formation
Other 1 Assay -
Other 1 Assay Method -
Other 2 Assay -
Other 2 Assay Method -
Other 3 Assay -
Other 3 Assay Method -
Karyotype Yes
Karyotype Assay -
Remaining Vector Detection Yes
Remaining Vector Detection Assay RT-PCR
STR -
HLA -
Stem Cell Transcriptome analysis Yes
Stem Cell Transcriptome analysis Assay qRT-PCR
Author Name(En) Tomo Saric
Author Name(Ja) Tomo Saric
Author Organization(En) Institute for Neurophysiology, Medical Center, University of Cologne
Author Organization(Ja) Institute for Neurophysiology, Medical Center, University of Cologne
Author Contact Email tomo[dot]saric[at]uni-koeln[dot]de
PI Organization(En) -
PI Organization(Ja) -
PI Name(En) -
PI Name(Ja) -
PI Contact Email -
Availability Information Only
Provider Organization(En) Institute for Neurophysiology, Medical Center, University of Cologne
Provider Organization(Ja) Institute for Neurophysiology, Medical Center, University of Cologne
Provider Email tomo[dot]saric[at]uni-koeln[dot]de
Provider URL -
Ethical Statement(En) -
Ethical Statement(Ja) -
Terms of Use(En) -
Terms of Use(Ja) -
PubMed ID 22178870
DOI 10.1159/000335753
Title In vitro Modeling of Ryanodine Receptor 2 Dysfunction Using Human Induced Pluripotent Stem Cells
Authors Azra Fatima, Guoxing Xu, Kaifeng Shao, Symeon Papadopoulos, Martin Lehmann, Juan J. Arnaiz-Cot, Angelo O. Rosa, Filomain Nguemo, Matthias Matzkies, Sven Dittmann, Susannah L. Stone, Matthias Linke, Ulrich Zechner, Vera Beyer, Hans Christian Hennies, Stephan Rosenkranz, Baerbel Klauke, Abdul S. Parwani, Wilhelm Haverkamp, Gabriele Pfitzer, Martin Farr, Lars Cleemann, Martin Morad, Hendrik Milting, Juergen Hescheler and Tomo Saric
Journal Cell Physiol Biochem
Year 2011
Volume 28
Issue 4
Pages 579-92
URL http://www.ncbi.nlm.nih.gov/pubmed/22178870
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