SKIP000922 |
SKIP ID |
SKIP000922 |
Organism(En) |
- |
Organism(Ja) |
- |
Cell Type(En) |
- |
Cell Type(Ja) |
- |
Cell Tissue(En) |
dermal fibroblast |
Cell Tissue(Ja) |
表皮繊維芽細胞 |
Cell Origin |
Diseased |
Cell Name 1(En) |
CPVT-iPS c1 |
Cell Name 1(Ja) |
CPVT-iPS c1 |
Cell Name 2(En) |
- |
Cell Name 2(Ja) |
- |
Disease Name 1(Ja) |
カテコラミン誘発多形性心室頻拍1型 |
ICD Code 1 |
I47.2 |
Disease Name 1(En) |
Catecholaminergic polymorphic ventricular tachycardia type 1 |
OMIM1 |
604772 |
Disease Name 2(Ja) |
- |
ICD Code 2 |
- |
Disease Name 2(En) |
- |
OMIM 2 |
- |
Disease Name 3(Ja) |
- |
ICD Code 3 |
- |
Disease Name 3(En) |
- |
OMIM 3 |
- |
Age |
46 |
Age Range |
40-49 |
Sex |
Female |
Race(En) |
- |
Race(Ja) |
- |
Genetic Diagnosis |
Yes |
Not Detected |
No |
Description(En) |
iPS cell line |
Description(Ja) |
iPS細胞 |
Cell Morphology |
human ES-like |
Grade |
Research Grade |
Vector |
Retrovirus |
Transgene |
SOX2, KLF4, OCT3/4 and c-MYC (pMX-based plasmids) |
Adhesiveness |
Yes |
Feeder |
Yes |
Feeder Cell |
irradiated MEFs |
Medium |
DMEM/F12 medium supplemented withGlutamax, 20% knockout serum replacer, 1% NAA, 0.1 mmol/L 2ME and 50 ng/ml bFGF |
Genome Editing |
- |
CO2 |
- |
Mycoplasma |
- |
Detection of Contaminants Mycoplasma |
- |
Pluripotent Markers |
Yes |
Pluripotent Markers Assay |
immunocytochemistry |
in vitro Differentiation |
Yes |
in vitro Differentiation Assay |
differentiation to cardiomyocytes |
in vivo Differentiation |
Yes |
in vivo Differentiation Assay |
teratoma formation |
Other 1 Assay |
- |
Other 1 Assay Method |
- |
Other 2 Assay |
- |
Other 2 Assay Method |
- |
Other 3 Assay |
- |
Other 3 Assay Method |
- |
Karyotype |
Yes |
Karyotype Assay |
- |
Remaining Vector Detection |
Yes |
Remaining Vector Detection Assay |
RT-PCR |
STR |
- |
HLA |
- |
Stem Cell Transcriptome analysis |
Yes |
Stem Cell Transcriptome analysis Assay |
qRT-PCR |
Author Name(En) |
Tomo Saric |
Author Name(Ja) |
Tomo Saric |
Author Organization(En) |
Institute for Neurophysiology, Medical Center, University of Cologne |
Author Organization(Ja) |
Institute for Neurophysiology, Medical Center, University of Cologne |
Author Contact Email |
tomo[dot]saric[at]uni-koeln[dot]de |
PI Organization(En) |
- |
PI Organization(Ja) |
- |
PI Name(En) |
- |
PI Name(Ja) |
- |
PI Contact Email |
- |
Availability |
Information Only |
Provider Organization(En) |
Institute for Neurophysiology, Medical Center, University of Cologne |
Provider Organization(Ja) |
Institute for Neurophysiology, Medical Center, University of Cologne |
Provider Email |
tomo[dot]saric[at]uni-koeln[dot]de |
Provider URL |
- |
Ethical Statement(En) |
- |
Ethical Statement(Ja) |
- |
Terms of Use(En) |
- |
Terms of Use(Ja) |
- |
PubMed ID |
22178870 |
DOI |
10.1159/000335753 |
Title |
In vitro Modeling of Ryanodine Receptor 2 Dysfunction Using Human Induced Pluripotent Stem Cells |
Authors |
Azra Fatima, Guoxing Xu, Kaifeng Shao, Symeon Papadopoulos, Martin Lehmann, Juan J. Arnaiz-Cot, Angelo O. Rosa, Filomain Nguemo, Matthias Matzkies, Sven Dittmann, Susannah L. Stone, Matthias Linke, Ulrich Zechner, Vera Beyer, Hans Christian Hennies, Stephan Rosenkranz, Baerbel Klauke, Abdul S. Parwani, Wilhelm Haverkamp, Gabriele Pfitzer, Martin Farr, Lars Cleemann, Martin Morad, Hendrik Milting, Juergen Hescheler and Tomo Saric |
Journal |
Cell Physiol Biochem |
Year |
2011 |
Volume |
28 |
Issue |
4 |
Pages |
579-92 |
URL |
http://www.ncbi.nlm.nih.gov/pubmed/22178870 |
Free input |
- |
Note |
- |