| SKIP000626 | |
| SKIP ID | SKIP000626 |
| Organism(En) | - |
| Organism(Ja) | - |
| Cell Type(En) | - |
| Cell Type(Ja) | - |
| Cell Tissue(En) | - |
| Cell Tissue(Ja) | - |
| Cell Origin | Diseased |
| Cell Name 1(En) | CiRA00021 |
| Cell Name 1(Ja) | CiRA00021 |
| Cell Name 2(En) | HP0327 |
| Cell Name 2(Ja) | HP0327 |
| Disease Name 1(Ja) | 筋萎縮性側索硬化症 |
| ICD Code 1 | G122 |
| Disease Name 1(En) | Amyotrophic Lateral Sclerosis |
| OMIM1 | 105400 |
| Disease Name 2(Ja) | - |
| ICD Code 2 | - |
| Disease Name 2(En) | - |
| OMIM 2 | - |
| Disease Name 3(Ja) | - |
| ICD Code 3 | - |
| Disease Name 3(En) | - |
| OMIM 3 | - |
| Age | - |
| Age Range | 50-59 |
| Sex | Male |
| Race(En) | Japanese |
| Race(Ja) | Japanese |
| Genetic Diagnosis | Yes |
| Not Detected | No |
| Description(En) | Disease specific iPS cell line derived from a patient : Amyotrophic lateral sclerosis. HPS0290 and HPS0291 are derived from the same patient. |
| Description(Ja) | 筋萎縮性側索硬化症（TDP-43遺伝子変異) iPS細胞。HPS0290、HPS0291と同一人由来。 |
| Cell Morphology | human ES-like |
| Grade | -- |
| Vector | Retrovirus |
| Transgene | Retroviral vector pMXs, Oct3/4, Sox2, Klf4, c-Myc |
| Adhesiveness | - |
| Feeder | Yes |
| Feeder Cell | SNL 76/7(X-rays:5000R or MMC) 1.5-2.5x10^(6)cells/100mm dish |
| Medium | Primate ES Cell Medium+4ng/mL human basic FGF |
| Genome Editing | - |
| CO2 | 5% |
| Mycoplasma | Negative |
| Detection of Contaminants Mycoplasma | - |
| Pluripotent Markers | - |
| Pluripotent Markers Assay | - |
| in vitro Differentiation | - |
| in vitro Differentiation Assay | - |
| in vivo Differentiation | - |
| in vivo Differentiation Assay | - |
| Other 1 Assay | - |
| Other 1 Assay Method | - |
| Other 2 Assay | - |
| Other 2 Assay Method | - |
| Other 3 Assay | - |
| Other 3 Assay Method | - |
| Karyotype | - |
| Karyotype Assay | - |
| Remaining Vector Detection | - |
| Remaining Vector Detection Assay | - |
| STR | - |
| HLA | - |
| Stem Cell Transcriptome analysis | - |
| Stem Cell Transcriptome analysis Assay | - |
| Author Name(En) | Haruhisa Inoue |
| Author Name(Ja) | 井上治久 |
| Author Organization(En) | Kyoto University, Center for iPS Cell Research and Application |
| Author Organization(Ja) | 京都大学iPS細胞研究所 |
| Author Contact Email | - |
| PI Organization(En) | - |
| PI Organization(Ja) | - |
| PI Name(En) | - |
| PI Name(Ja) | - |
| PI Contact Email | - |
| Availability | Available |
| Provider Organization(En) | RIKEN BioResource Center |
| Provider Organization(Ja) | 理化学研究所バイオリソースセンター |
| Provider Email | cellips[at]brc[dot]riken[dot]jp |
| Provider URL | http://www2.brc.riken.jp/lab/cell/detail.cgi?cell_no=HPS0327 |
| Ethical Statement(En) | - |
| Ethical Statement(Ja) | - |
| Terms of Use(En) | - |
| Terms of Use(Ja) | - |
| PubMed ID | 22855461 |
| DOI | 10.1126/scitranslmed.3004052 |
| Title | Drug screening for ALS using patient-specific induced pluripotent stem cells. |
| Authors | Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H |
| Journal | Sci Transl Med |
| Year | 2012 |
| Volume | 4 |
| Issue | 145 |
| Pages | 145ra104 |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/22855461 |
| Free input | - |
| Note | - |