SKIP000994 |
SKIP ID |
SKIP000994 |
Organism(En) |
- |
Organism(Ja) |
- |
Cell Type(En) |
- |
Cell Type(Ja) |
- |
Cell Tissue(En) |
- |
Cell Tissue(Ja) |
- |
Cell Origin |
Diseased |
Cell Name 1(En) |
PARK8-LB21 |
Cell Name 1(Ja) |
PARK8-LB21 |
Cell Name 2(En) |
- |
Cell Name 2(Ja) |
- |
Disease Name 1(Ja) |
遺伝性パーキンソン病:PARK8 |
ICD Code 1 |
G20 |
Disease Name 1(En) |
PARKINSON DISEASE 8, AUTOSOMAL DOMINANT; PARK8 |
OMIM1 |
607060 |
Disease Name 2(Ja) |
- |
ICD Code 2 |
- |
Disease Name 2(En) |
- |
OMIM 2 |
- |
Disease Name 3(Ja) |
- |
ICD Code 3 |
- |
Disease Name 3(En) |
- |
OMIM 3 |
- |
Age |
78 |
Age Range |
70-79 |
Sex |
Female |
Race(En) |
- |
Race(Ja) |
- |
Genetic Diagnosis |
Yes |
Not Detected |
No |
Description(En) |
iPS cells from familial Parkinson's disease patient |
Description(Ja) |
遺伝性パーキンソン病患者由来iPS細胞 |
Cell Morphology |
human ES-like |
Grade |
Research Grade |
Vector |
Lentivirus |
Transgene |
Klf4, Sox2, Oct4, c-Myc |
Adhesiveness |
- |
Feeder |
Yes |
Feeder Cell |
MSTO |
Medium |
hES medium |
Genome Editing |
- |
CO2 |
3% |
Mycoplasma |
Negative |
Detection of Contaminants Mycoplasma |
- |
Pluripotent Markers |
Yes |
Pluripotent Markers Assay |
Immunostaining |
in vitro Differentiation |
Yes |
in vitro Differentiation Assay |
- |
in vivo Differentiation |
Yes |
in vivo Differentiation Assay |
Teratoma assay |
Other 1 Assay |
- |
Other 1 Assay Method |
- |
Other 2 Assay |
- |
Other 2 Assay Method |
- |
Other 3 Assay |
- |
Other 3 Assay Method |
- |
Karyotype |
Yes |
Karyotype Assay |
- |
Remaining Vector Detection |
Yes |
Remaining Vector Detection Assay |
qRT-PCR |
STR |
- |
HLA |
- |
Stem Cell Transcriptome analysis |
- |
Stem Cell Transcriptome analysis Assay |
- |
Author Name(En) |
Etsuro Ohta |
Author Name(Ja) |
Etsuro Ohta |
Author Organization(En) |
Kitazato University |
Author Organization(Ja) |
Kitazato University |
Author Contact Email |
- |
PI Organization(En) |
- |
PI Organization(Ja) |
- |
PI Name(En) |
- |
PI Name(Ja) |
- |
PI Contact Email |
- |
Availability |
Information Only |
Provider Organization(En) |
- |
Provider Organization(Ja) |
- |
Provider Email |
- |
Provider URL |
- |
Ethical Statement(En) |
- |
Ethical Statement(Ja) |
- |
Terms of Use(En) |
- |
Terms of Use(Ja) |
- |
PubMed ID |
26056228 |
DOI |
10.1093/hmg/ddv212 |
Title |
I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway. |
Authors |
Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H |
Journal |
Hum Mol Genet |
Year |
2015 |
Volume |
- |
Issue |
- |
Pages |
- |
URL |
http://www.ncbi.nlm.nih.gov/pubmed/26056228 |
Free input |
- |
Note |
- |