SKIP000994
SKIP ID SKIP000994
Organism(En) -
Organism(Ja) -
Cell Type(En) -
Cell Type(Ja) -
Cell Tissue(En) -
Cell Tissue(Ja) -
Cell Origin Diseased
Cell Name 1(En) PARK8-LB21
Cell Name 1(Ja) PARK8-LB21
Cell Name 2(En) -
Cell Name 2(Ja) -
Disease Name 1(Ja) 遺伝性パーキンソン病:PARK8
ICD Code 1 G20
Disease Name 1(En) PARKINSON DISEASE 8, AUTOSOMAL DOMINANT; PARK8
OMIM1 607060
Disease Name 2(Ja) -
ICD Code 2 -
Disease Name 2(En) -
OMIM 2 -
Disease Name 3(Ja) -
ICD Code 3 -
Disease Name 3(En) -
OMIM 3 -
Age 78
Age Range 70-79
Sex Female
Race(En) -
Race(Ja) -
Genetic Diagnosis Yes
Not Detected No
Description(En) iPS cells from familial Parkinson's disease patient
Description(Ja) 遺伝性パーキンソン病患者由来iPS細胞
Cell Morphology human ES-like
Grade Research Grade
Vector Lentivirus
Transgene Klf4, Sox2, Oct4, c-Myc
Adhesiveness -
Feeder Yes
Feeder Cell MSTO
Medium hES medium
Genome Editing -
CO2 3%
Mycoplasma Negative
Detection of Contaminants Mycoplasma -
Pluripotent Markers Yes
Pluripotent Markers Assay Immunostaining
in vitro Differentiation Yes
in vitro Differentiation Assay -
in vivo Differentiation Yes
in vivo Differentiation Assay Teratoma assay
Other 1 Assay -
Other 1 Assay Method -
Other 2 Assay -
Other 2 Assay Method -
Other 3 Assay -
Other 3 Assay Method -
Karyotype Yes
Karyotype Assay -
Remaining Vector Detection Yes
Remaining Vector Detection Assay qRT-PCR
STR -
HLA -
Stem Cell Transcriptome analysis -
Stem Cell Transcriptome analysis Assay -
Author Name(En) Etsuro Ohta
Author Name(Ja) Etsuro Ohta
Author Organization(En) Kitazato University
Author Organization(Ja) Kitazato University
Author Contact Email -
PI Organization(En) -
PI Organization(Ja) -
PI Name(En) -
PI Name(Ja) -
PI Contact Email -
Availability Information Only
Provider Organization(En) -
Provider Organization(Ja) -
Provider Email -
Provider URL -
Ethical Statement(En) -
Ethical Statement(Ja) -
Terms of Use(En) -
Terms of Use(Ja) -
PubMed ID 26056228
DOI 10.1093/hmg/ddv212
Title I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.
Authors Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H
Journal Hum Mol Genet
Year 2015
Volume -
Issue -
Pages -
URL http://www.ncbi.nlm.nih.gov/pubmed/26056228
Free input -
Note -