| SKIP001188 | |
| SKIP ID | SKIP001188 |
| Organism(En) | - |
| Organism(Ja) | - |
| Cell Type(En) | - |
| Cell Type(Ja) | - |
| Cell Tissue(En) | Glioma |
| Cell Tissue(Ja) | 悪性膠芽腫 |
| Cell Origin | Diseased |
| Cell Name 1(En) | GNS481 |
| Cell Name 1(Ja) | GNS481 |
| Cell Name 2(En) | G481 |
| Cell Name 2(Ja) | G481 |
| Disease Name 1(Ja) | 多形膠芽腫 |
| ICD Code 1 | C719 |
| Disease Name 1(En) | Glioblastoma multiforme |
| OMIM1 | 131550 |
| Disease Name 2(Ja) | - |
| ICD Code 2 | - |
| Disease Name 2(En) | - |
| OMIM 2 | - |
| Disease Name 3(Ja) | - |
| ICD Code 3 | - |
| Disease Name 3(En) | - |
| OMIM 3 | - |
| Age | 64 |
| Age Range | 60-69 |
| Sex | Female |
| Race(En) | - |
| Race(Ja) | - |
| Genetic Diagnosis | No |
| Not Detected | No |
| Description(En) | GNS cells were patient-derived tumour cells established and maintained as an adherent monolayer. Refractory to TMZ, but susceptible to cell death when treated with both TMZ and DRD4 antagonist. |
| Description(Ja) | 多形膠芽腫患者の腫瘍細胞由来の神経膠芽腫幹細胞 |
| Cell Morphology | fibroblast-like |
| Grade | Research Grade |
| Vector | -- |
| Transgene | - |
| Adhesiveness | - |
| Feeder | -- |
| Feeder Cell | - |
| Medium | - |
| Genome Editing | - |
| CO2 | - |
| Mycoplasma | - |
| Detection of Contaminants Mycoplasma | - |
| Pluripotent Markers | Yes |
| Pluripotent Markers Assay | - |
| in vitro Differentiation | - |
| in vitro Differentiation Assay | - |
| in vivo Differentiation | Yes |
| in vivo Differentiation Assay | intracranial transplantation into immunocompromised mice |
| Other 1 Assay | - |
| Other 1 Assay Method | - |
| Other 2 Assay | - |
| Other 2 Assay Method | - |
| Other 3 Assay | - |
| Other 3 Assay Method | - |
| Karyotype | - |
| Karyotype Assay | - |
| Remaining Vector Detection | - |
| Remaining Vector Detection Assay | - |
| STR | - |
| HLA | - |
| Stem Cell Transcriptome analysis | - |
| Stem Cell Transcriptome analysis Assay | - |
| Author Name(En) | Peter B. Dirks |
| Author Name(Ja) | 多形膠芽腫患者の腫瘍細胞由来の神経膠芽腫幹細胞 |
| Author Organization(En) | Arthur and Sonia Labatt Brain Tumor Research Center and Developmental and Stem Cell Biology, The Hospital for Sick Children (SickKids) |
| Author Organization(Ja) | Arthur and Sonia Labatt Brain Tumor Research Center and Developmental and Stem Cell Biology, The Hospital for Sick Children (SickKids) |
| Author Contact Email | - |
| PI Organization(En) | Arthur and Sonia Labatt Brain Tumor Research Center and Developmental and Stem Cell Biology, The Hospital for Sick Children (SickKids) |
| PI Organization(Ja) | Arthur and Sonia Labatt Brain Tumor Research Center and Developmental and Stem Cell Biology, The Hospital for Sick Children (SickKids) |
| PI Name(En) | Peter B. Dirks |
| PI Name(Ja) | Peter B. Dirks |
| PI Contact Email | - |
| Availability | Information Only |
| Provider Organization(En) | - |
| Provider Organization(Ja) | - |
| Provider Email | - |
| Provider URL | - |
| Ethical Statement(En) | - |
| Ethical Statement(Ja) | - |
| Terms of Use(En) | - |
| Terms of Use(Ja) | - |
| PubMed ID | 27300435 -- 19497285 -- 23108137 |
| DOI | 10.1016/j.ccell.2016.05.002 -- 10.1016/j.stem.2009.03.014 -- 10.1158/0008-5472.CAN-12-1881 |
| Title | Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. -- Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. -- A tumorigenic MLL-homeobox network in human glioblastoma stem cells. |
| Authors | Dolma S, Selvadurai HJ, Lan X, Lee L, Kushida M, Voisin V, Whetstone H, So M, Aviv T, Park N, Zhu X, Xu C, Head R, Rowland KJ, Bernstein M, Clarke ID, Bader G, Harrington L, Brumell JH, Tyers M, Dirks PB -- Pollard SM, Yoshikawa K, Clarke ID, Danovi D, Stricker S, Russell R, Bayani J, Head R, Lee M, Bernstein M, Squire JA, Smith A, Dirks P -- Gallo M, Ho J, Coutinho FJ, Vanner R, Lee L, Head R, Ling EK, Clarke ID, Dirks PB |
| Journal | Cancer Cell -- Cell Stem Cell -- Cancer Res |
| Year | 2016 -- 2009 -- 2012 |
| Volume | 29 -- 4 -- 73 |
| Issue | 6 -- 6 -- 1 |
| Pages | 859-73 -- 568-80 -- 417-27 |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/27300435 -- http://www.ncbi.nlm.nih.gov/pubmed/19497285 -- http://www.ncbi.nlm.nih.gov/pubmed/23108137 |
| Free input | -- -- |
| Note | - |