| SKIP000514 | |
| SKIP ID | SKIP000514 |
| Organism(En) | - |
| Organism(Ja) | - |
| Cell Type(En) | - |
| Cell Type(Ja) | - |
| Cell Tissue(En) | - |
| Cell Tissue(Ja) | - |
| Cell Origin | Normal |
| Cell Name 1(En) | WD39 |
| Cell Name 1(Ja) | WD39 |
| Cell Name 2(En) | - |
| Cell Name 2(Ja) | - |
| Disease Name 1(Ja) | - |
| ICD Code 1 | - |
| Disease Name 1(En) | - |
| OMIM1 | - |
| Disease Name 2(Ja) | - |
| ICD Code 2 | - |
| Disease Name 2(En) | - |
| OMIM 2 | - |
| Disease Name 3(Ja) | - |
| ICD Code 3 | - |
| Disease Name 3(En) | - |
| OMIM 3 | - |
| Age | 16 |
| Age Range | 10-19 |
| Sex | Female |
| Race(En) | - |
| Race(Ja) | - |
| Genetic Diagnosis | -- |
| Not Detected | No |
| Description(En) | Induced pluripotent stem cell (iPSC) line derived from dermal fibroblast; retroviruses used contained human Oct3/4, Sox2, Klf4 and c-Myc. Healthy iPSC line. |
| Description(Ja) | 皮膚線維芽細胞にレトロウイルスベクターを用いてOct3/4, Sox2, Klf4, c-Mycの4因子を導入して樹立したヒト人工多能性幹細胞（iPSC）を樹立。 健常者由来iPS細胞株。 |
| Cell Morphology | human ES-like |
| Grade | Research Grade |
| Vector | Retrovirus |
| Transgene | SOX2, OCT4, KLF4, c-Myc |
| Adhesiveness | - |
| Feeder | Yes |
| Feeder Cell | Mitomycin-C-treated murine fibroblast feeder cells |
| Medium | standard hESC medium (Dulbecco's modified Eagle's medium [DMEM]/F12 [Sigma] containing 20% KnockOut serum replacement [KSR; Life Technologies], nonessential amino acids [NEAA], 0.1 mM 2-mercaptoethanol [Sigma], and 4 ng/ml fibroblast growth factor 2 [FGF-2] [PeproTech]) |
| Genome Editing | - |
| CO2 | - |
| Mycoplasma | - |
| Detection of Contaminants Mycoplasma | - |
| Pluripotent Markers | Yes |
| Pluripotent Markers Assay | - |
| in vitro Differentiation | Yes |
| in vitro Differentiation Assay | - |
| in vivo Differentiation | Yes |
| in vivo Differentiation Assay | teratoma formation |
| Other 1 Assay | - |
| Other 1 Assay Method | - |
| Other 2 Assay | - |
| Other 2 Assay Method | - |
| Other 3 Assay | - |
| Other 3 Assay Method | - |
| Karyotype | Yes |
| Karyotype Assay | - |
| Remaining Vector Detection | - |
| Remaining Vector Detection Assay | - |
| STR | - |
| HLA | - |
| Stem Cell Transcriptome analysis | - |
| Stem Cell Transcriptome analysis Assay | - |
| Author Name(En) | Hideyuki Okano |
| Author Name(Ja) | 岡野 栄之 |
| Author Organization(En) | Department of Physiology, Keio University School of Medicine |
| Author Organization(Ja) | 慶應義塾大学 医学部 生理学教室 |
| Author Contact Email | hidokano[at]a2[dot]keio[dot]jp |
| PI Organization(En) | Department of Physiology, Keio University School of Medicine |
| PI Organization(Ja) | 慶應義塾大学 医学部 生理学教室 |
| PI Name(En) | Hideyuki Okano |
| PI Name(Ja) | 岡野 栄之 |
| PI Contact Email | hidokano[at]a2[dot]keio[dot]jp |
| Availability | Information Only |
| Provider Organization(En) | Department of Physiology, Keio University School of Medicine |
| Provider Organization(Ja) | 慶應義塾大学 医学部 生理学教室 |
| Provider Email | akamatsu[at]a7[dot]keio[dot]jp |
| Provider URL | - |
| Ethical Statement(En) | - |
| Ethical Statement(Ja) | - |
| Terms of Use(En) | - |
| Terms of Use(Ja) | - |
| PubMed ID | 23039195 -- 24936452 |
| DOI | 10.1186/1756-6606-5-35 -- 10.1016/j.stemcr.2014.03.007 |
| Title | Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. -- Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes. |
| Authors | Imaizumi Y, Okada Y, Akamatsu W, Koike M, Kuzumaki N, Hayakawa H, Nihira T, Kobayashi T, Ohyama M, Sato S, Takanashi M, Funayama M, Hirayama A, Soga T, Hishiki T, Suematsu M, Yagi T, Ito D, Kosakai A, Hayashi K, Shouji M, Nakanishi A, Suzuki N, Mizuno Y, Mizushima N, Amagai M, Uchiyama Y, Mochizuki H, Hattori N, Okano H -- Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H |
| Journal | Mol Brain -- Stem Cell Reports |
| Year | 2012 -- 2014 |
| Volume | 5 -- 2 |
| Issue | -- 5 |
| Pages | 35 -- 648-61 |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/23039195 -- http://www.ncbi.nlm.nih.gov/pubmed/24936452 |
| Free input | -- |
| Note | - |