| SKIP000532 | |
| SKIP ID | SKIP000532 |
| Organism(En) | - |
| Organism(Ja) | - |
| Cell Type(En) | - |
| Cell Type(Ja) | - |
| Cell Tissue(En) | - |
| Cell Tissue(Ja) | - |
| Cell Origin | Diseased |
| Cell Name 1(En) | HHT human iPS cell |
| Cell Name 1(Ja) | HHT human iPS cell |
| Cell Name 2(En) | - |
| Cell Name 2(Ja) | - |
| Disease Name 1(Ja) | 遺伝性出血性毛細管拡張症 |
| ICD Code 1 | I78.0 |
| Disease Name 1(En) | Hereditary haemorrhagic telangiectasia |
| OMIM1 | 187300 |
| Disease Name 2(Ja) | - |
| ICD Code 2 | - |
| Disease Name 2(En) | - |
| OMIM 2 | - |
| Disease Name 3(Ja) | - |
| ICD Code 3 | - |
| Disease Name 3(En) | - |
| OMIM 3 | - |
| Age | - |
| Age Range | -- |
| Sex | -- |
| Race(En) | - |
| Race(Ja) | - |
| Genetic Diagnosis | Yes |
| Not Detected | No |
| Description(En) | Human skin fibroblasts were reprogrammed by retroviral overexpression of the four transcription factors OCT3/4, SOX-2, KLF4 and C-MYC, the most reproducible method described to date. iPS cells from somatic cells of patients who suffer from hereditary haemorrhagic telangiectasia (HHT). |
| Description(Ja) | 遺伝性出血性毛細管拡張症由来iPS細胞。 ヒト皮膚線維芽細胞にレトロウイルスで4因子（OCT3/4, SOX-2, KLF4 and C-MYC）導入することにより初期化した。 |
| Cell Morphology | human ES-like |
| Grade | Research Grade |
| Vector | Retrovirus |
| Transgene | OCT3/4, SOX-2, KLF4 and C-MYC |
| Adhesiveness | - |
| Feeder | Yes |
| Feeder Cell | Mitomycin C-treated SNL feeder cells |
| Medium | Primate ES cell medium supplemented with 4 ng/ml bFGF |
| Genome Editing | - |
| CO2 | - |
| Mycoplasma | - |
| Detection of Contaminants Mycoplasma | - |
| Pluripotent Markers | Yes |
| Pluripotent Markers Assay | - |
| in vitro Differentiation | Yes |
| in vitro Differentiation Assay | - |
| in vivo Differentiation | - |
| in vivo Differentiation Assay | - |
| Other 1 Assay | - |
| Other 1 Assay Method | - |
| Other 2 Assay | - |
| Other 2 Assay Method | - |
| Other 3 Assay | - |
| Other 3 Assay Method | - |
| Karyotype | - |
| Karyotype Assay | - |
| Remaining Vector Detection | - |
| Remaining Vector Detection Assay | - |
| STR | - |
| HLA | - |
| Stem Cell Transcriptome analysis | - |
| Stem Cell Transcriptome analysis Assay | - |
| Author Name(En) | C.L. Mummery |
| Author Name(Ja) | C.L. Mummery |
| Author Organization(En) | Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands |
| Author Organization(Ja) | Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands |
| Author Contact Email | - |
| PI Organization(En) | Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands |
| PI Organization(Ja) | Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands |
| PI Name(En) | C.L. Mummery |
| PI Name(Ja) | C.L. Mummery |
| PI Contact Email | - |
| Availability | Information Only |
| Provider Organization(En) | Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands |
| Provider Organization(Ja) | Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands |
| Provider Email | c[dot]l[dot]mummery[at]lumc[dot]nl |
| Provider URL | - |
| Ethical Statement(En) | - |
| Ethical Statement(Ja) | - |
| Terms of Use(En) | - |
| Terms of Use(Ja) | - |
| PubMed ID | 20111645 |
| DOI | - |
| Title | The first reported generation of human induced pluripotent stem cells (iPS cells) and iPS cell-derived cardiomyocytes in the Netherlands. |
| Authors | Freund C, Davis RP, Gkatzis K, Ward-van Oostwaard D, Mummery CL |
| Journal | Neth Heart J |
| Year | 2010 |
| Volume | 18 |
| Issue | 1 |
| Pages | 51-4 |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/20111645 |
| Free input | - |
| Note | - |