| SKIP000873 | |
| SKIP ID | SKIP000873 |
| Organism(En) | - |
| Organism(Ja) | - |
| Cell Type(En) | - |
| Cell Type(Ja) | - |
| Cell Tissue(En) | - |
| Cell Tissue(Ja) | - |
| Cell Origin | Diseased |
| Cell Name 1(En) | NR1 |
| Cell Name 1(Ja) | NR1 |
| Cell Name 2(En) | - |
| Cell Name 2(Ja) | - |
| Disease Name 1(Ja) | 1型双極性障害 |
| ICD Code 1 | F31 |
| Disease Name 1(En) | manic type I bipolar disorder |
| OMIM1 | 125480 |
| Disease Name 2(Ja) | 心的外傷後ストレス障害 |
| ICD Code 2 | F431 |
| Disease Name 2(En) | post traumatic stress disorder |
| OMIM 2 | - |
| Disease Name 3(Ja) | - |
| ICD Code 3 | - |
| Disease Name 3(En) | - |
| OMIM 3 | - |
| Age | 54 |
| Age Range | 50-59 |
| Sex | Male |
| Race(En) | - |
| Race(Ja) | - |
| Genetic Diagnosis | No |
| Not Detected | No |
| Description(En) | iPS cell derived from fibroblasts of a patient with manic type I bipolar disorder not responsive to lithium treatment |
| Description(Ja) | 1型双極性障害患者由来iPS細胞、患者はリチウム治療により症状の改善が見られない |
| Cell Morphology | human ES-like |
| Grade | Research Grade |
| Vector | Sendai virus |
| Transgene | using Cyto-Tune Sendai reprogramming kit (Invitrogen) with Oct-3/4, Sox2, Klf4, c-Myc |
| Adhesiveness | - |
| Feeder | No |
| Feeder Cell | - |
| Medium | mTeSR1 |
| Genome Editing | - |
| CO2 | - |
| Mycoplasma | Negative |
| Detection of Contaminants Mycoplasma | - |
| Pluripotent Markers | Yes |
| Pluripotent Markers Assay | immunostaining, RT-PCR |
| in vitro Differentiation | Yes |
| in vitro Differentiation Assay | qRT-PCR |
| in vivo Differentiation | - |
| in vivo Differentiation Assay | - |
| Other 1 Assay | - |
| Other 1 Assay Method | - |
| Other 2 Assay | - |
| Other 2 Assay Method | - |
| Other 3 Assay | - |
| Other 3 Assay Method | - |
| Karyotype | Yes |
| Karyotype Assay | - |
| Remaining Vector Detection | Yes |
| Remaining Vector Detection Assay | RT-PCR |
| STR | - |
| HLA | - |
| Stem Cell Transcriptome analysis | - |
| Stem Cell Transcriptome analysis Assay | - |
| Author Name(En) | Jerome Mertens -- Fred H. Gage |
| Author Name(Ja) | Jerome Mertens -- Fred H. Gage |
| Author Organization(En) | Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal University -- The Salk Institute for Biological Studies, Laboratory of Genetics |
| Author Organization(Ja) | Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal University -- The Salk Institute for Biological Studies, Laboratory of Genetics |
| Author Contact Email | -- |
| PI Organization(En) | Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal University -- The Salk Institute for Biological Studies, Laboratory of Genetics |
| PI Organization(Ja) | Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal University -- The Salk Institute for Biological Studies, Laboratory of Genetics |
| PI Name(En) | Jun Yao -- Fred H. Gage |
| PI Name(Ja) | Jun Yao -- Fred H. Gage |
| PI Contact Email | -- |
| Availability | Information Only |
| Provider Organization(En) | - |
| Provider Organization(Ja) | - |
| Provider Email | - |
| Provider URL | - |
| Ethical Statement(En) | - |
| Ethical Statement(Ja) | - |
| Terms of Use(En) | - |
| Terms of Use(Ja) | - |
| PubMed ID | 26524527 |
| DOI | 10.1038/nature15526 |
| Title | Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. |
| Authors | Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, degaard KJ, McCarthy MJ, Zandi PP, Alda M, Nievergelt CM, Pharmacogenomics of Bipolar Disorder Study, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J |
| Journal | Nature |
| Year | 2015 |
| Volume | 527 |
| Issue | 7576 |
| Pages | 95-9 |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/26524527 |
| Free input | - |
| Note | - |