SKIP000804
SKIP ID SKIP000804
Organism(En) -
Organism(Ja) -
Cell Type(En) -
Cell Type(Ja) -
Cell Tissue(En) -
Cell Tissue(Ja) -
Cell Origin Diseased
Cell Name 1(En) HCG-1-#32
Cell Name 1(Ja) HCG-1-#32
Cell Name 2(En) -
Cell Name 2(Ja) -
Disease Name 1(Ja) 軟骨低発生症
ICD Code 1 Q774
Disease Name 1(En) Hypochondrogenesis
OMIM1 200610
Disease Name 2(Ja) -
ICD Code 2 -
Disease Name 2(En) -
OMIM 2 -
Disease Name 3(Ja) -
ICD Code 3 -
Disease Name 3(En) -
OMIM 3 -
Age -
Age Range 0-9
Sex Male
Race(En) -
Race(Ja) -
Genetic Diagnosis Yes
Not Detected No
Description(En) Hypochondrogenesis(S2011-43)-specific iPS cells.
Description(Ja) Ⅱ型コラーゲン異常症(軟骨低発生症)患者線維芽細胞(S2011-43)由来iPS細胞
Cell Morphology human ES-like
Grade Research Grade
Vector Other
Transgene Mixture Y4: OCT3/4 , SOX2 , KLF4 , L-MYC , LIN28 , and p53 shRNA
Adhesiveness -
Feeder Yes
Feeder Cell Mitomycin-C-treated mouse embryonic fibroblasts
Medium MEM/F12 (Sigma) with 20% Knockout Serum Replacement (Invitrogen), 2 m m l -glutamine, 100 μ m non-essential amino acids, 100 μ m β -mercaptoethanol, 4 ng/ml bFGF (Wako), 50 U/ml penicillin and 50 μg/ml streptomycin
Genome Editing -
CO2 -
Mycoplasma -
Detection of Contaminants Mycoplasma -
Pluripotent Markers Yes
Pluripotent Markers Assay Immunocytochemical analysis
in vitro Differentiation Yes
in vitro Differentiation Assay -
in vivo Differentiation Yes
in vivo Differentiation Assay Teratoma formation
Other 1 Assay -
Other 1 Assay Method -
Other 2 Assay -
Other 2 Assay Method -
Other 3 Assay -
Other 3 Assay Method -
Karyotype No
Karyotype Assay -
Remaining Vector Detection -
Remaining Vector Detection Assay -
STR -
HLA -
Stem Cell Transcriptome analysis -
Stem Cell Transcriptome analysis Assay -
Author Name(En) Minoru Okada
Author Name(Ja) 岡田 稔
Author Organization(En) Center for iPS Cell Research and Application, Kyoto University
Author Organization(Ja) 京都大学iPS細胞研究所
Author Contact Email -
PI Organization(En) -
PI Organization(Ja) -
PI Name(En) -
PI Name(Ja) -
PI Contact Email -
Availability Information Only
Provider Organization(En) Center for iPS Cell Research and Application,Kyoto University
Provider Organization(Ja) 京都大学iPS細胞研究所 CiRA
Provider Email -
Provider URL https://www.cira.kyoto-u.ac.jp/e/index.html
Ethical Statement(En) -
Ethical Statement(Ja) -
Terms of Use(En) -
Terms of Use(Ja) -
PubMed ID 25187577
DOI 10.1093/hmg/ddu444
Title Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells.
Authors Okada M, Ikegawa S, Morioka M, Yamashita A, Saito A, Sawai H, Murotsuki J, Ohashi H, Okamoto T, Nishimura G, Imaizumi K, Tsumaki N
Journal Hum Mol Genet
Year 2014
Volume 24
Issue 2
Pages 299-313
URL http://www.ncbi.nlm.nih.gov/pubmed/25187577
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